We present a novel approach for generating targeted deletions of genomic segments in human and other eukaryotic cells using engineered zinc finger nucleases (ZFNs). We found that ZFNs designed to target two different sites in a human chromosome could introduce two concurrent DNA double-strand breaks (DSBs) in the chromosome and give rise to targeted deletions of the genomic segment between the ...

We discuss the deletion of a single vertex in a Delaunay tetrahedralization (DT). While some theoretical solutions exist for this problem, the many degeneracies in three dimensions make them impossible to be implemented without the use of extra mechanisms. In this paper, we present an algorithm that uses a sequence of bistellar flips to delete a vertex in a DT, and we present two different mech...