PURPOSE The present a novel adenocarcinoma model in athymic mice. METHODS Seven athymic mice were used. Colon diversion and distal fistula were made. Adenocarcinoma cells were inoculated in the submucosa of fistula. Tumor growth was monitored daily. Scintigraphy with 99mTc-MIBI was performed to identify the tumor. RESULTS The model of distal colon cancer is feasible. Tumor detection was pos...

Our study reveals a non-canonical role for CCL2 in modulating non-macrophage, myeloid-derived suppressor cells (MDSCs) and shaping a tumor-permissive microenvironment during colon cancer development. We found that intratumoral CCL2 levels increased in patients with colitis-associated colorectal cancer (CRC), adenocarcinomas, and adenomas. Deletion of CCL2 blocked progression from dysplasia to a...

the chloroform soluble fractions of ethanolic extracts of five inula belonging to the compositae family were evaluated for cytotoxic activity against five different cell lines including caco2 (human colon adenocarcinoma), mcf7 (human breast adenocarcinoma), hepg2 (human hepatocellular carcinoma), vero (green african monkey kidney) and wehi164 (balb c mouse fibrosarcoma). cytotoxicity was assess...

introduction: transient cavitations induced by low frequency irradiation of ultrasound can be used to treat tumors. previous studies in in-vitro experiments have shown that induced cavitation by dual or multiple frequencies of ultrasound is greater than induced cavitation by single frequency irradiation. in this study, we compared and evaluated the treatment effects of dual frequency irradiatio...

background and aim: the aim of this study was to investigate the epidemiological features of colorectal cancer in imam reza hospital in kermanshah, iran, in a five-year period. materials and methods: this cross-sectional study included all the patients (n=167) admitted to imam reza hospital in kermanshah over a five-year period, diagnosed with colorectal cancer through performing colonoscopy an...

Background: Adenocarcinoma of the prostate is an invasive carcinoma, a neoplasm epithelial cells with secretory cell differentiation. Histomorphology glandular. The are sheets or single neoplasia, basal not seen in this carcinoma. Tumor-Infiltrating Lymphocytes (TILs) lymphocytes that migrate to tumor peritumoral cells. In malignancy, T lymphocyte infiltration can be found, indicating immune re...

cancer stem cells (cscs) are unique subpopulations that have the capacity to drive malignant progression with renewal abilities. recently the role of some of cscs in gastric adenocarcinoma has been studied. this study was performed in order to evaluate cd44 and cd133 expressions by immunohistochemistry in 95 primary gastric adenocarcinoma and their relation to clinical and pathological paramete...

Pancreatic adenocarcinoma, one of the worst malignancies of the exocrine pancreas, is a solid tumor with increasing incidence and mortality in industrialized countries. This condition is usually driven by oncogenic KRAS point mutations and evolves into a highly aggressive metastatic carcinoma due to secondary gene mutations and unbalanced expression of genes involved in the specific signaling p...

nasal sinuses representing about 70% of malignant tumors. Only between 10% and 20% correspond to adenocarcinomas mostly originated in the minor submucous glands. Less frequent tumors originate in the cavity lining epithelium, such as intestinal-type adenocarcinoma (ITA) and low-grade adenocarcinoma (LGA). The ITA, described by Jarvi in 1945 1 , is also known as mucinous adenocarcinoma, colon ad...