Adrenal tumors are very rare. These lesions called adrenal incidentalomas because they incidentally detected through imaging procedure. Its prevalence ranges from 1.4% to 2.9% worldwide. Clinical suspicion, laboratory testing, Imaging and histopathological examination needed for definite diagnosis. We report three cases of received at our institute between the year 2021 2022. Pheochromocytoma g...

The failure of certain adrenal tumors to respond to ACTH was investigated in vivo be administration of corticotropin-(1-24)-tetracosapeptide (ACTH1-24) and dexamethasone and in vitro by studying the binding properties of ACTH1-24 and prostaglandin E1 (PGE1) and their effect on adenylate cyclase activity of the tumors' crude membranes; in addition, in five cases the stimulation of cortisol produ...

The function of the hypophyseo-adrenocortical system was investigated by the method described by Robinson, Mattingly, and Cope (1962), based on the principle that if the system is functionally normal the blood cortisol level, which is decreased in the course of corticosteroid therapy, returns to normal after steroid withdrawal. In a number of asthmatic children on steroid therapy the blood cort...

Gonads and adrenal glands are the primary organs for the production of steroid hormones in mammals. Steroid hormones play important roles in development and are essential for the maintenance of homeostasis during adult life. To supply sufficient amounts of hormones, gonads and adrenal glands maintain their functions by replenishment of steroidogenic cells. It has been hypothesized that stem/pro...

1. Plasma cortisol concentration was measured in three subjects with homozygous familial hypercholesterolaemia immediately before, and 30 and 60 min after, an intramuscular injection of adrenocorticotrophic hormone. The baseline values and the values at 30 and 60 min were within the normal range. 2. We conclude that in the presence of a genetic deficiency of low-density lipoprotein receptors, t...

The fact that depletion of sodium and of chloride may occur in acute porphyria, in the absence of alkalosis due to vomiting, has recently been noted independently by Abrahams, Gavey and Maclagan (1) and by Linder (2). These authors suggested that a possible basis for this deficiency was that of adrenal cortical failure, but the response of their two patients to substitution therapy with cortica...

It has been shown that adrenocorticotropic hormone will increase the phosphorylase activity of beef adrenal cortical slices in vitro (1). On the basis of this and other observations the hypothesis was proposed that the ACTHl effect on corticoid biosynthesis is mediated by the increased levels of TPNH which result from dehydrogenation of glucose 6-phosphate arising at an accelerated rate from gl...

To a further understanding of the role of steroid hormones in adrenal disorders, we have prepared free cell system of adrenal cells, using adrenal tissues thai had been removed by operation from (i) cases of Cushing's syndrome due to adrenocortical adenoma or adrenocortical hyperplasia, (ii) a case of primary aldosteronism, and (iii) a patient with virilizing adrenal tumor. Twelve important ste...