In their recent editorial Mannion and Braithwaite provide an insightful critique of traditional patient safety improvement efforts, and offer a powerful alternative vision based on Safety-II thinking that has the potential to radically transform the way we approach patient safety. In this commentary, I explore how the Safety-II perspective points to new directions for organisational learning in...

many cultures have developed folk herbal remedies for various symptoms of mental illness. an evidence base now is being developed for some of these “alternative” herbal remedies. there has been an increase in the number and proportion of clinical trials of complementary medicine, which suggests a trend toward an evidence-based approach. this review presents the scientific information regarding ...

28 We examined developmental programming studies that reported sex-specific effects 29 published between 2012 and 2014, and examined whether the authors reported a 30 statistical approach to explicitly test whether the effect of treatment differed between the 31 sexes, e.g., a sex by treatment interaction term. Less than half of the studies that reported 32 sex-specific effects described explic...

The planning of large infrastructure projects such as inner-city subway tracks is a highly collaborative process in which numerous experts from different domains are involved. While performing the planning task, widely differing scales have to be taken into consideration, ranging from the kilometer scale for the general routing of the track down to the centimeter scale for the detailed design o...