The RH blood group locus is composed of two sequence-related genes, RHD and RHCE, encoding the D, Cc, and Ee antigens in common Rh-positive phenotypes. In this report, we have analyzed the molecular basis of Rh antigens expression in weak D (Du) and RN donors, in whom there is a severe reduction of the D and C/e antigens, respectively. Genomic and transcript analysis of three unrelated low-grad...

We have shown previously that the Rhesus (Rh) polypeptides are the commonest targets for pathogenic anti-red blood cell (RBC) autoantibodies in patients with autoimmune hemolytic anemia (AIHA). The aim of the current work was to determine whether activated T cells from such patients also mount recall responses to epitopes on these proteins. Two panels of overlapping 15-mer peptides, correspondi...

Group O D-negative blood cells are universal donors in transfusion medicine and methods for converting other blood groups into this universal donor group have been researched. However, conversion of D-positive cells into D-negative is yet to be achieved, although conversion of group A or B cells into O cells has been reported. The Rh D blood group is determined by the RHD gene, which encodes a ...

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a clinically defined, inflammatory central nervous system (CNS) disease of unknown cause, associated with humoral autoimmune findings such as anti-aquaporin 4 (AQP4)-IgG. Recent clinical trials showed benefit anti-B cell and anti-complement-antibodies in NMOSD, suggesting relevance anti-AQP4-IgG pathogenesis. Objective: AQP4-IgG NMOS...

OBJECTIVE To report a case with unusual ABO discrepancies caused by coexistence of the loss of anti-B isoagglutinin and rouleau formation. CLINICAL PRESENTATION AND INTERVENTION A 79-year-old female diagnosed as having multiple myeloma (MM) with monoclonal IgG-λ type showed rouleau formation in peripheral blood smear. The ABO and Rh blood type before the diagnosis of MM was A+, but the follow...

Systemically or centrally administered agmatine (decarboxylated arginine) prevents, moderates, or reverses opioid-induced tolerance and self-administration, inflammatory and neuropathic pain, and sequelae associated with ischemia and spinal cord injury in rodents. These behavioral models invoke the N-methyl-D-aspartate (NMDA) receptor/nitric-oxide synthase cascade. Agmatine (AG) antagonizes the...

Sốt xuất huyết Dengue là một bệnh truyền nhiễm cấp tính do virus gây ra, lây qua muỗi Aedes. Nghiên cứu này đánh giá số đặc điểm học, chức năng gan, kháng thể ở 253 nhân (BN) sốt Dengue. Kết quả nghiên cho thấy chỉ anti-DENV-IgM, anti-DENV-IgG thay đổi rõ rệt giữa nhóm (DF) và có dấu hiệu cảnh báo (DWS) (p<0,05). Có mối liên quan tăng hoạt độ ALT AST, giảm lượng tiểu cầu DF hoặc anti-DENV-Ig...

Prior to the availability of anti-D immunoglobulin (anti-D Ig), the incidence of Rh(D) alloimmunisation in D negative women following two deliveries of D positive, ABO-compatible infants was approximately 16%, and haemolytic disease of the newborn (HDN) due to anti-D was a significant cause of morbidity and mortality. Following routine post-partum administration of anti-D Ig, the rate of alloim...