fenugreek (trigonella foeum-graecum l.) has been used in iranian traditional medicine for treatment of different kinds of inflammation disorders. in the present study, anti- inflammatory activity of the methanolic extract of the plant (at doses of 100, 200 and 400 mg/kg) were studied using carrageenan-induced edema method and compared with the effects of dexamethasone and ibuprofen. various con...

The use of agonist antibodies to costimulatory receptors holds significant promise as a complementary approach to the already proven strategy of antibody mediated checkpoint blockade. This is in part due to the multiple mechanisms that have been associated with targeting costimulatory molecules in mouse models such as expansion of antigen-specific effector T cells (Teff), decrease in number or ...

Endostatin has novel ATPase activity, which mediates its anti-angiogenic and anti-tumor activities Shan Wang, Xin-an Lu, Peng Liu, Yan Fu, Lin Jia, Shunli Zhan, and Yongzhang Luo Authors' Affiliations: The National Engineering Laboratory for Anti-tumor Protein Therapeutics; Beijing Key Laboratory for Protein Therapeutics; and Cancer Biology Laboratory, School of Life Sciences, Tsinghua Universi...

Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that capable killing virally infected and physiologically stressed cells, like tumor cells. In addition to their ability directly kill cancer NK enhancing both antibody T-cell responses. Moreover, ex vivo activation, expansion, genetic modification can greatly enhance anti-tumor activity equip them overcome resistan...

Ganoderma lucidum (G lucidum) is a medicinal fungus with a variety of biological activities. It has long been used as a folk remedy for promotion of health and longevity in China and other oriental countries. The most attractive character of this kind of medicinal fungus is its immunomodulatory and anti-tumor activities. Large numbers of studies have shown that G lucidum modulate many component...

eybees from the bud or bark of certain coniferous trees, has long been used in folk medicine. Several studies on the isolated chemical components of propolis have reported a number of biological responses including antibacterial, anti-fungal, anti-inflammatory and anti-tumor activities. In particular, 3,4-dihydroxycinnamic acid phenetyl ester (CAPE) displays various potent anti-tumor effects. C...

Procyanidins present in grape seeds are known to exert anti-inflammatory, anti-arthritic and anti-allergic activities, prevent skin aging, scavenge oxygen free radicals and inhibit UV radiation-induced peroxidation activity. Since most of these events are associated with the tumor promotion stage of carcinogenesis, these studies suggest that grape seed polyphenols and the procyanidins present t...

The expression of Triggering Receptor Expressed on Myeloid cells ( TREM)-1 has been described as a predictive marker for anti-Tumor Necrosis Factor (TNF)-? monoclonal antibody (mAb) therapy responsiveness in patients with inflammatory bowel disease (IBD). Here we investigated TREM-1 specifically CD14+ monocytes relation to anti-TNF response. pretreatment levels Crohn’s (CD) were outcome mAb the...