Hyponatremia (serum sodium level less than 134 mmol/L) is a common electrolyte disturbance. Its high prevalence and potential neurologic sequelae make a logical and rigorous differential diagnosis mandatory before any therapeutic intervention. A history of concurrent illness and medication use as well as the assessment of extracellular volume status on physical examination may provide useful cl...

Tumors from patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) have been found to contain large amounts of the antidiuretic hormone vasopressin. A lung tumor from a patient with hyponatremia most likely due to SIADH was removed at surgery and found to contain 23.5 mU vasopressin/g wet weight by radioimmunoassay Slices of this tumor were incubated with phenylal...

HONG, SUK KI, CHUN SIK PARK, YANG SAENG PARK, AND JIN KYUNG KIM. Seasonal changes of antidiuretic hormone action on sodium transport acruss frog skin. Am. J. Physiol. 215(2) : 439-443. 1968.-The stimulating effect of antidiuretic hormone (ADH) on Na transport across isolated frog skin (Runa temporuriu) was studied monthly, along with the glycogen contents of liver and muscle. ADH induced a sust...

Vasopressin, or antidiuretic hormone, is a peptide hormone that is released from the posterior pituitary gland in response to changes in blood pressure and plasma osmolality. The main pathophysiological states associated with high plasma vasopressin concentrations are cirrhosis, cardiac failure and syndrome of inappropriate antidiuretic hormone (SIADH) secretion. Pharmacological treatments for ...

The factors responsible for congestive heart failure as a clinical syndrome may be multiple. Although decreased cardiac output relative to inflow produces a moderate increase in venous pressure, there is a concomitant decrease in renal blood flow which may contribute to a decreased renal excretion of sodium. There is also a decrease in hepatic inactivation ( ? due to congestion) of adrenal cort...

The effect of antidiuretic hormone (ADH) on the release of immunoreactive alpha-melanocyte stimulating hormone (alpha-MSH) from the superfused neurointermediate lobe of the pituitary of the normal Wistar and Brattleboro (diabetes insipidus) rat was studied in vitro. In control experiments, there was usually an initial peak, after which alpha-MSH release fell exponentially over the course of the...