We present the case of a 69-year-old Caucasian and non-smoker patient with erythematous, itchy, violaceous lesions on the ankles, wrists, lower legs, forearms and trunk developed within 15 months. Her condition was diagnosed as prurigo and she was treated for a long period of time with antihistaminic drugs, with no resolution of lesions. In October 2008, she presented to a Private Practice of D...

Background and Objective: Paliperidone is an active metabolite of risperidone which received FDA approval very recently. Because of its unique pharmacologic delivery system and low avidity for D2 receptor lower doses of paliperidone (3 mg & 6 mg) are claimed to be much safer from EPS point of view. We aim to present a case of cervico-oromandibular dystonia in a young adult with schizophrenia te...

With slices derived from two areas of guinea pig brain, cerebellum, and cerebrum plus brain stem, we have shown that specific, and different, receptors exist in these two brain areas for the control of cyclic adenosine 3’,5’-monophosphate (cyclic AMP) levels. The cerebellum contains a single type of receptor, shown to be a classical /3-adrenergic receptor. The remainder of the brain was shown t...

Cimetidine is the prototype antiulcer drug having the imidazole nucleus and acts by blocking histamine H2 receptors. Keeping this context in mind, an attempt has been made to study the antihistaminic activity of some novel 1-substituted imidazole derivatives on isolated guinea pig atria to reveal their desired pharmacological effects. In the present revision, some 1-substituted Imidazoles (1a-1...

In the previous years the synthesis of high nitrogen containing heterocyclic systems has been attracted to many pharmaceutical and agrochemical industries. The triazole nucleus is one of the most important heterocycles which is a feature of natural products and medicinal agents. Triazole nucleus is enjoying their importance as being the center of activity. The nitrogen containing heterocyclics ...

Chlorpheniramine, a histamine H1 receptor antagonist, was assayed for in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum K1 strain and chloroquine-resistant P. falciparum T9/94 clone, by measuring the 3H-hypoxanthine incorporation. Chlorphenirame inhibited P. falciparum K1 and T9/94 growth with IC50 values of 136.0+/-40.2 microM and 102.0+/-22.6 microM respectively...

I. The Toxicity of Some Zirconium and Thorium Salts in Rats. L. T. McClinton and Jack Schubert 1 II. The Potentiating Effect of Antihistaminic Drugs Upon the Sedative Action of Barbiturates. Charles A. Winter . 7 III. Studies on Hydrocarbon-Epinephrine Induced Ventricular Fibrillation. Solomon Garb and Maynard B. Chenoweth 12 IV. The Inhibition of the Cholinesterase of Rat Brain by Methadon. Ge...