BACKGROUND The mutations that confer resistance to antiviral agents are thought to be detrimental, or at best neutral, to influenza virus fitness. The fact that resistant influenza strains can circulate and sometimes replace sensitive strains is of great public health concern. OBJECTIVES We used mathematical modeling to test various hypotheses about the transmission of antiviral-resistant inf...

background and objective: cytomegalovirus (cmv) infections are associated with severe morbidity and mortality in patients, especially pediatric renal transplantation patients. the use of immunosuppressive agents places these patients at the risk of viral infections. as cytomegalovirus infection influences the graft outcome, adopting useful strategies for limiting this virus after transplantatio...

Antiviral textiles are one of the most promising areas protective textiles. important in field health and hygiene. They become an essential part our daily-life when a pandemic situation arises. The present paper critically analyses summarizes various researches production antiviral Different classes virus, how virus transmits replicates, agents for their working mechanism, application procedure...

BACKGROUND & AIMS Only half of patients with chronic hepatitis C virus (HCV) infection experience sustained virologic response to pegylated-interferon and ribavirin, which cause numerous side effects. Thus, the identification of more effective and better tolerated agents is a high priority. We applied chemical biology to screen small molecules that regulate HCV. METHODS We first optimized the...

Objectives Echovirus 30 is a major cause of meningitis in children and adults. The aim of this study was to investigate whether the antifungal drug itraconazole could exhibit antiviral activity against echovirus 30. Methods The cytopathic effect and viral RNA levels were assessed in RD cells as indicators of viral replication. The effects of itraconazole were compared to those of two known an...

Formycin is a naturally occurring C-glycoside (C-nucleoside) that possesses antitumor, antibacterial, antifungal, and antiviral activity. In connection with our ongoing interest in the design and syntheses of C-nucleoside derived antiviral agents this report describes the preparation of carbocyclic formycin and its 7-hydroxy (oxo) analog lacking the C-40 hydroxylmethylene moiety in racemic form...

the influenza viruses are major etiologic agents of human respiratory infections, and inflict a sizable health and economic burden. this study examines the antiinfluenza virus activity of hydroalcoholic extract of olive leaves (olhe). olive leaves were collected from gardens around the city of shiraz, characterized, dried, ground to powder, and its hydroalcoholic extract was prepared. the influ...