Basidial fungi have long been known as sources of antitumor compounds such as polysaccharides. Studies conducted by scientists from different countries demonstrate that polysaccharides and other fungal compounds (proteins, glycoproteins, terpenoids, melanins, nucleosides, etc.) exhibit antiviral activity against many viruses pathogenic for humans. The review presents data on the studied antivir...

objective(s) the aim of this study was to search for new antiviral agents from herbal medicines. ethanol extracts of c. semipervirens, c. semipervirens var. horizontalis and c. semipervirens cv. cereiformis were used in experiments to test their influence on herpes viruses (hsv-1). materials and methods hela cells monolayers were infected with herpes viruses (hsv-1). antiviral activity of the p...

conclusions further studies on the role of hepcidin in pathogenesis of chc are needed to assess the potency of its use in antiviral treatment. results patients with chc had lower hepcidin mrna expression and more frequently iron deposits in hepatocytes than subjects with chb did. in chc group, hepcidin mrna expression was positively correlated with alanine aminotransferase activity and serum ir...

AS1411 is a G-rich aptamer that forms a stable G-quadruplex structure and displays antineoplastic properties both in vitro and in vivo. This oligonucleotide has undergone phase 2 clinical trials. The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also present in the cell membrane where it selectively mediates the binding and uptake of AS1411. Cell-surfa...

RNase L, a principal mediator of innate immunity to viral infections in higher vertebrates, is required for a complete IFN antiviral response against certain RNA stranded viruses. dsRNA produced during viral infections activates IFN-inducible synthetases that produce 5'-phosphorylated, 2',5'-oligoadenylates (2-5A) from ATP. 2-5A activates RNase L in a wide range of different mammalian cell type...

The consumption of green tea (Camellia sinensis) has been shown to have many physiological and pharmacological health benefits. In the past two decades several studies have reported that epigallocatechin-3-gallate (EGCG), the main constituent of green tea, has anti-infective properties. Antiviral activities of EGCG with different modes of action have been demonstrated on diverse families of vir...

background and aims: human adenoviruses can cause a diversity of clinical diseases, but there is no antiviral therapy formally approved by adenovirus infections. thus, antiviral agents derived from medicinal plants which are effective against adenoviruses infections are urgently required. therefore, this research was aimed to evaluate in vitro antiadenovirus activity of pomegranate (punica gran...

objectives: evaluation of therapeutic effects of carum copticum (c. copticum) has been the subject of several studies in recent years. thymol the major component of c. copticum is a widely known anti-microbial agent. in this study, the antibacterial and anti viral activities of essential oil of c. copticum fruit were determined. materials and methods: essential oil of c. copticum was analyzed b...