The effects of teicoplanin (8 micrograms/ml), ampicillin (64 micrograms/ml), imipenem (32 micrograms/ml), and gentamicin (4 micrograms/ml), alone and in combination, against 13 unique blood isolates of vancomycin-resistance (MIC for 90% of isolates tested [MIC90], 512 micrograms/ml), teicoplanin-susceptible (MIC90, 2.0 micrograms/ml), ampicillin-resistant (MIC90, 128 micrograms/ml), and non-bet...

Rats irradiated with 600 r (total body) showed increased indices of both opsonophagic and surface phagocytosis 2, 12, and 24 hours after irradiation. The indices decreased 72 hours after exposure and returned to normal by the 4th to 5th postirradiation day. Bactericidal power of the blood of irradiated animals was depressed when measured 3 and 6 days after exposure to x-rays. Decomplemented ser...

was prevented completely by DW-224a at concentrations of 1·, 2· and 4· MIC by 24 h, although regrowth occurred in the presence of ciprofloxacin at 1· MIC concentration. DW-224a also showed a dose-dependent bactericidal activity against all test organisms up to 4· the MIC. The MBCs of DW-224a in Mueller–Hinton broth (MHB) were identical to 1·MIC or at most twice the MIC for all strains tested. B...

OBJECTIVES Staphylococcus aureus small colony variants (SCVs) are slow-growing morphological variants associated with persistent infections. While vancomycin activity has been shown to be attenuated against SCVs of S. aureus, few data exist regarding daptomycin. The objective was to evaluate the pharmacodynamics of daptomycin against defined S. aureus mutants displaying the SCV phenotype. MET...

We conducted the following study to determine if bispecific antibodies enhance the bactericidal activity of bovine neutrophils. Bispecific antibodies were synthesized by chemically crosslinking bovine neutrophil monoclonal antibodies to Staphylococcus aureus 305 capsule polysaccharide monoclonal antibodies. The efficiency of chemically coupling monoclonal antibody monomers was approximately 50%...

The bactericidal activity of 23 beta-lactam antibiotics was compared in slowly growing bacteria cultured in a chemostat. In an attempt to mimic possible in vivo conditions, slowly growing cultures were produced by limitation of iron, glucose, phosphate, or magnesium. Only select antibiotics remained effectively bactericidal against slowly growing cells. For these compounds, the rate of antibiot...