Stem cells in adult tissues share two defining characteristics – cell division is self-renewing and asymmetric. In the Drosophila oogenic germline, the self-renewing aspect of the division produces a new stem cell that remains associated with a complement of somatic cells (terminal filament cells, cap cells and inner sheath cells; collectively, somatic tip cells) that maintain a supportive micr...

UNLABELLED Many if not most proteins function in oligomeric assemblies of one or more protein sequences. The Protein Data Bank provides coordinates for biological assemblies for each entry, at least 60% of which are dimers or larger assemblies. BioAssemblyModeler (BAM) is a graphical user interface to the basic steps in homology modeling of protein homooligomers and heterooligomers from the bio...

Cyclins regulate progression through the cell cycle. Control of cyclin levels is essential in Drosophila oogenesis for the four synchronous divisions that generate the 16 cell germ line cyst and for ensuring that one cell in each cyst, the oocyte, is arrested in meiosis, while the remaining fifteen cells become polyploid nurse cells. Changes in cyclin levels could be achieved by regulating tran...

Microarray hybridization or antibody binding can be detected by many techniques, however, only a few are suitable for widespread use since many of these detection techniques rely on bulky and expensive instruments. Here, we describe the usefulness of a simple and inexpensive detection method based on gold nanoparticle labeled antibodies visualized by a commercial, office desktop flatbed scanner...

Bidirectionality, forward and backward information flow, is introduced in neural networks to produce two-way associative search for stored stimulus-response associations (A(i),B(i)). Two fields of neurons, F(A) and F(B), are connected by an n x p synaptic marix M. Passing information through M gives one direction, passing information through its transpose M(T) gives the other. Every matrix is b...

[1] A 1 km vertical section of etched terrain and hematite-bearing plains materials and nearby cratered terrain surfaces was mapped in the northern portion of Meridiani Planum using MOC, THEMIS, MOLA, and OMEGA data. The oldest materials are the cratered plains, which have 0.4 to 2.5 mm spectral reflectance dominated by a mix of low and high calcium pyroxenes. Etched plains materials overlie th...

Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, ...