Although a glucocorticoid (GC)-sparing strategy is needed for patients with giant cell arteritis (GCA) suffering from refractory disease or serious treatment-related complications, evidence of efficacy in this setting of immunosuppressive drugs and biotherapies is lacking. Herein, we evaluated the GC-sparing effects and tolerability of addition of dapsone (DDS) to prednisone therapy in patients...

Objective: Limited research has examined the psychometric properties of death depression scales in Persian populations with cardiac disease despite the need for valid assessment tools for evaluating depressive symptoms in patients with life-limiting chronic conditions. The present study aimed at evaluating the reliability and validity of the Persian Version of Death Depression Scale - Revised (...

Drug delivery systems (DDS) based on poly (lactide-co-glycolide) (PLGA) microspheres and nanospheres have been separately studied in previous works as a means of delivering bioactive compounds over an extended period of time. In the present study, two DDS having different sizes of the PLGA spheres were compared in morphology, drug (dexamethasone) loading efficiency and drug release kinetics in ...

Dapsone (DDS) hydroxylamine metabolites cause oxidative stress- linked adverse effects in patients, such as methemoglobin formation and DNA damage. This study evaluated the ameliorating effect of the antioxidant resveratrol (RSV) on DDS hydroxylamine (DDS-NHOH) mediated toxicity in vitro using human erythrocytes and lymphocytes. The antioxidant mechanism was also studied using in-silico methods...

Through analysis on principles of Binary Phase Shift Keying(2PSK) modulation and demodulation, the design scheme based on DSP Builder of DDS (Direct Digital frquency Synthesizer) is put forward. By using DSP Builder complete modulation and demodulation model, carrier signal was generated by DDS signal source. The circuit hardware structure of this design is simple and easy to implement. The mod...

Simplest (and most expensive) approach may be to combine the outputs of N number of separate signal generators through an N-way power divider. Digital sources, such as a direct digital synthesizer (DDS), can also be used to generate multiple tones, although at a more limited total bandwidth and with less output power than separate signal generators. Similarly, a vector signal generator, which i...