Given data y and k covariates x one problem in linear regression is to decide which in any of the covariates to include when regressing y on the x. If k is small it is possible to evaluate each subset of the x. If however k is large then some other procedure must be use. Stepwise regression and the lasso are two such procedures but they both assume a linear model with error term. A different ap...

A series of 2-benzoxazolinone, diazocoumarin and quinazoline derivatives have been shown to inhibit HIV replication in cell culture. To understand the pharmacophore properties of selected molecules and design new anti-HIV agents, quantitative structure–activity relationship (QSAR) study was developed using a descriptor selection approach based on the stepwise method. Multiple linear regression ...

One of the most important aspects of software project management is the estimation of cost and time required for running information system. Therefore, software managers try to carry estimation based on behavior, properties, and project restrictions. Software cost estimation refers to the process of development requirement prediction of software system. Various kinds of effort estimation patter...

COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure–activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method. The built model was robust and predictive with correlation coefficient (R2) of 0.972 and 0.531 for training and test groups, respectively. The quality of the mod...

Our approach of rule-based reenement 1 provides a formal description for the stepwise system development based on Petri nets. Rules with a left-hand and a right-hand side allow replacing subnets in a given algebraic high-level net system. The extension of these rules supports the preservation of system properties. In this paper we extend the preservation of safety properties signiicantly. We de...