Objective(s): The novel 1,5-diaryl-1,4-pentadien-3-one derivatives were studied for analgesic, anti-inflammatory and anticancer potential to establish their role in pain, inflammatory disorders and cancer.Materials and Methods: Two 1,5- diaryl-1,4-pentadien-3-one derivatives: (1E,4E)- 5-(4-fluoro phenyl)-1-(4-methoxyphenyl)- 2-methylpenta-1,4-dien-3-one (A2K2A17) and  (1E,4E)-5-(4-nitrophenyl)-...

Drug Docking The binding of linoleate and other potential ligands to the recently discovered fatty acid site in SARS-CoV-2 spike protein is investigated by James Spencer, Adrian J. Mulholland et al. their Research Article on page 7098.

This paper is designed to examine the binding behavior of Coumarin with bovine -casein (βCN) through fluorescence spectroscopy and molecular modeling techniques. The data analysis on fluorescence titration experiments at various temperatures represents the enthalpy driven nature for the formation of Coumarin–βCN complex and the prevailed role of hydrogen bonds and van der Waals interactions in...

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an emerging virus responsible for the ongoing Disease 19 (COVID-19) pandemic. Despite advent of COVID-19 vaccines, pandemic fatigue still escalating as new SARS-CoV-2 variants emerge and vaccine shortages hit globally. Hence, drug repurposing remains alternative strategy to combat SARS-CoV-2. For centuries, plants have served natur...

The scientific review presents the mechanisms of action cytoplasmic miRNAs, namely posttranscriptional silencing: TNRC6-associated mechanism miRNA-mediated mRNA degradation. To write article, information was searched using databases Scopus, Web Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, Cochrane Library, CyberLeninka. It is known that in cytoplasm cells cases short region,...

     Most of the biological phenomena are influenced by intermolecular recognition and interaction. Thus, understanding the thermodynamics of biomacromolecule ligand interaction is a very interesting area in biochemistry and biotechnology. One of the most powerful techniques to obtain precise information about the energetics of (bio) molecules binding to other biological macromolecules is isoth...

Tetrodotoxin (TTX)-binding proteins are present in toxic TTX-bearing animals, such as pufferfish and gastropods. These may prevent autotoxicity. However, TTX-binding also found the nontoxic marine shore crab, Hemigrapsus sanguineus. Here, we isolated protein, HSTBP (Hemigrapsus sanguineus protein), from hemolymph of H. elucidated its primary structure using cDNA cloning. HSTBP, a 400 kDa acidic...