Stem Cell Lineage Fate Highly accurate, efficient, and convenient evaluation for biomaterial-induced stem cell lineage fate is pivotal regenerative biomaterials research. In article number 2210637, Binbin Lai, Xuehui Zhang, Xuliang Deng, co-workers report MeD-P, a machine-learning-supported intelligent model, predicting human mesenchymal cell–biomaterial interaction based on RNA-seq data. This ...

Objective: The genus Ferula L. includes perennial flowering plants belonging to the Apiaceae family. This genus is a rich source of biologically active phytochemicals such as sulfur-containing derivatives, coumarins, sesquiterpenes, sesquiterpene lactones, sesquiterpene coumarins, glucuronic acid, galactose, arabinose, rhamnose, and daucane esters. Over the last decade, considerable attention h...

One of the most important issues in biomedical research microscopy is the analysis of the spatial localization of fluorescently labelled structures. Today, a wide range of available dyes, fluorescent proteins and labelling techniques allows the creation of complex multicolored samples to study intracellular localization. However, analysis of localization and colocalization is often perturbed by...

Studying PrPC and PrPSc in cell culture systems is advantageous because such systems contain all the organelles, membranes, and molecular cofactors that are likely to play an important role in the biology of the proteins. Using cultured cells expressing PrPC, we have discovered that this isoform constitutively cycles between the cell surface and an endocytic compartment, a process that is media...

Introduction: Radiation from cell phones has been associated with an increased risk of cancer. The literature has reported evidence of certain biological effects resulting from exposure to various wavelengths, doses, and intensities of radiofrequency radiation. The present study aimed to evaluate the possible adverse effects of radiation from a GSM mobile phone operating at 900 MHz on human mel...

Nanotechnology is a rapidly growing field having potential applications in many areas. Nanoparticles (NPs) have been studied for cell toxicity, immunotoxicity, and genotoxicity. Tetrazolium-based assays such as MTT, MTS, and WST-1 are used to determine cell viability. Cell inflammatory response induced by NPs is checked by measuring inflammatory biomarkers, such as IL-8, IL-6, and tumor necrosi...

Introduction: Nowadays, cell therapy is the most advanced treatment of peripheral nerve injury. The aim of this study was to determine the effects of transplantation of hair follicle stem cells on the regeneration of the sciatic nerve injury in rats. Methods: The bulge region of the rat whisker was isolated and cultured. Morphological and biological features of the cultured bulge cells were ob...

nano-silver (agnp) has biological properties which are significant for consumer products, food technology, textiles and medical applications (e.g. wound care products, implantable medical devices, in diagnosis, drug delivery, and imaging). for their antibacterial activity, silver nanoparticles are largely used in various commercially available products. thus, the use of nano-silver is becoming ...

background: the aim of this study was to fabricate the poly caprolactone (pcl) aligned nanofiber scaffold and to evaluate the survival, adhesion, proliferation, and differentiation of rat hair follicle stem cells (hfsc) in the graft material using electrospun pcl nanofiber scaffold for tissue engineering applications. methods: the bulge region of rat whisker was isolated and cultured in dmem: n...