Mohammad Abdollahi
Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. Toxicology and Poisoning Research Center and Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - In vitro protection of human lymphocytes from toxic effects of chlorpyrifos by selenium-enriched medicines
Objective(s): Chlorpyrifos (CP) is a broad-spectrum organophosphorus pesticide used extensively in agricultural and domestic pest control, accounting for 50% of the global insecticidal use. In the present study, protective effects of two selenium-enriched strong antioxidative medicines IMOD and Angipars were examined in human lymphocytes treated with CP in vitro. Materials and Methods: Isolate...
[ 2 ] - The efficacy and prophylactic characteristics of omega-3 fatty acids in experimental gingivitis in rats
Objective(s):Gingivitis is an inflammatory disease that affects tooth-supporting tissues and is caused by a microbe-immune response. The aim of this study was to evaluate the effects of omega-3 fatty acids on immune system regulation and the prevention and treatment of gingivitis using an animal model. Materials and Methods: Gingival inflammation was induced by lipopolysaccharide (LPS) injectio...
[ 3 ] - Anti-Aging Effects of Some Selected Iranian Folk Medicinal Herbs-Biochemical Evidences
Objective(s): In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. Materials and Methods: Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/kg/day for 6 weeks). A positive control group was assigned...
[ 4 ] - Toxicity of Nanoparticles and an Overview of Current Experimental Models
Nanotechnology is a rapidly growing field having potential applications in many areas. Nanoparticles (NPs) have been studied for cell toxicity, immunotoxicity, and genotoxicity. Tetrazolium-based assays such as MTT, MTS, and WST-1 are used to determine cell viability. Cell inflammatory response induced by NPs is checked by measuring inflammatory biomarkers, such as IL-8, IL-6, and tumor necrosi...
[ 5 ] - Swertia longifolia Boiss has beneficial effects on hepatic and renal functions in diabetic rats
Introduction: Diabetes is a multifactorial syndrome with high prevalence which may induce serious disorders in the body organs like the liver and kidney. This study aimed to compare the effects of the alcoholic extract of the aerial parts of Swertia longifolia Boiss on blood glucose, lipid profiles and liver and kidney function tests in streptozotocin-induced diabetes. Methods: Thirty five male...
[ 6 ] - Mechanistic assessment of cadmium toxicity in association with the functions of estrogen receptors in the Langerhans islets
Objective(s): Diabetes is a metabolic disease with an increasing prevalence for which finding new and efficient therapeutic approaches has always been a challenge. Preserving integrity and functionality of pancreatic β-cells as the only source of insulin in the body is such a case. To achieve this goal different cellular targets have been proposed among which pancreatic estrogen receptors have ...
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