Cancer may soon become the leading disease-related cause of human death in many countries of the world. In the United States, cancer is projected to surpass cardiovascular disease as the major cause of death. Nevertheless, there is good news forthcoming with respect to emerging breakthrough drugs that demonstrate our increased understanding of cancer at the molecular level, a greater focus on m...

Many a science writer has fantasized about capping a story with the headline “Good News for Sick Mice!” One of the toughest struggles is deciding how to cover a story that has produced tantalizing, even amazing, results in laboratory animals but could well be a total bust by the time it gets to humans. That issue came up in early July, when Elan Pharmaceuticals, an Irish company with laboratori...

Background. The precision and limitations of ventricular pacemapping as a method to localize the site of earliest breakthrough of ventricular tachycardia (VT) were investigated in a canine model of experimental myocardial infarction. Methods and Results. Forty-one episodes of VT induced in 10 animals were mapped using a standard grid of 64 endocardial and epicardial bipolar electrodes to determ...

Background. We have previously shown that 75% of individuals on antiretroviral therapy (ART) in a resource-limited setting who experienced virological breakthrough to >1000 copies/mL were resuppressed after an intensive adherence intervention. This study examines the long-term outcomes of this group in order to understand the impact of the adherence intervention over time. Methods. ART-naïve ad...

BACKGROUND Endo-epicardial dissociation (EED) of electric activations resulting in transmural conduction of fibrillation waves (breakthroughs) has been postulated to contribute to the complexity of the substrate of atrial fibrillation (AF). The aim of this study was to elucidate the correlation between EED and incidence of breakthrough and to test the plausibility of transmural conduction versu...

OBJECTIVE Rapid analgesic onset opioids, particularly fentanyl buccal tablet, is preferable for managing breakthrough pain. The efficacy and safety of fentanyl buccal tablet and its association with around-the-clock opioids needs to be explored with an option of dose adjustments, more closely reflecting administration in clinical practice. The aim of the study was to assess the safety and effic...