The development of organometallic catalysts with high activity and selectivity has transformed the way both bulk and fine chemicals are produced. When such catalysts are applied in fine chemicals production, the presence of toxic heavy metals in these catalysts (Pd, Pt, Ru, Rh, etc.) can pose significant separation challenges. Regulatory bodies (such as the FDA and EMA) require that many popula...

J. W. Cleary, R. E. Peale,* D. J. Shelton, G. D. Boreman, C. W. Smith, M. Ishigami, R. Soref, A. Drehman, and W. R. Buchwald Department of Physics, University of Central Florida, Orlando, Florida 32816, USA College of Optics (CREOL), University of Central Florida, Orlando, Florida 32816, USA Sensors Directorate, Air Force Research Laboratory, Hanscom Air Force Base, Massachusetts 01731, USA *Co...

Over the last 10–15 years, there has been a pervasive trend toward initiation of chronic dialysis at higher levels of estimated GFR (eGFR) across a range of different patient groups and practice settings (1–5). This finding seems to suggest that on average patients are now initiating chronic dialysis substantially earlier in the course of their kidney disease than in previous years (3). In ligh...

Chapter 1. Suzuki-Miyaura coupling reactions of aryl and heteroaryl halides with aryl-, heteroaryl and vinyl boronic acids proceed in very good to excellent yield with the use of 2-(2',6'-dimethoxybiphenyl)dicyclohexylphosphine, SPhos. Additionally, a comparison of the reactions with SPhos and with 2(2',4',6'-triisoprocpylbiphenyl)-diphenylphosphine is presented that is informative in determini...

Selective functionalization reactions of aromatic and heteroaromatic halides with carbon, oxygen, and nitrogen nucleophiles have attracted much attention in the last decades. In addition to typical metal-catalyzed coupling reactions, direct functionalization of aryl halides through the formation of Grignard reagents offer new ways for the efficient construction of biologically interesting carbo...