Objective(s): The aim of the present study is to determine the effect of Chloramphenicol (CAP) on rat liver and small intestine. Effect of phenobarbital (PB) on CAP toxicity was also investigated.   Materials and Methods:   Rats were received CAP at doses of 0, 200, 400 and 600 mg/kg. Another group was pretreated with 80 mg/kg PB 30 min prior to administration of various doses...

Melatonin, a major hormone of pineal gland, was recently show to attenuate acute gastric lesions induced by strong irritants because of the scavenging of free radicals. The effect of melatonin on burninduced gastric mucosal injury due to the skin burn is unclear. PURPOSE: This study investigated heme oxygenase-1 and markers linked with oxidative stress in gastric mucosa and the effect of melato...

BACKGROUND One of the effects of burn injury is production of reactive oxygen species increasing general-structural damage. Such a condition is called oxidative stress. The purpose of this research was to find out whether oxidative stress is present in burnt children treated routinely and, if so, in which phase of the disease it is the most severe and how long it persists. MATERIAL AND METHOD...

Burn injury is associated with a loss of gut barrier function, resulting in systemic dissemination of gut-derived bacteria and their products. The bacterial protein and TLR5 agonist, flagellin, induces non-specific innate immune responses. Because we detected flagellin in the serum of burn patients, we investigated whether gut-derived flagellin was a primary or secondary contributor to intestin...

Background and purpose: Cancer is one of the major health challenges in the world. The efficacy of current treatments is low but their side effects are high. Cold atmospheric plasma (CAP) is a new modality for cancer treatment. This study aimed to compare the cytotoxicity effect of CAP on the cell line models of common cancers and normal cells. Materials and methods: In this experimental study...

BACKGROUND Acute renal failure (ARF) is not a rare occurrence in severe burns and is an important complication leading to an increase in mortality. The severity of the burn is largely determined by the burn size, and severe burns are likely to cause enough loss of extracellular fluid and albumin from plasma volume to produce shock and hypoalbuminemia. HYPOTHESIS We hypothesized that initial s...

Many studies have reported that zinc plasma levels significantly decrease after a burn, leading to zinc deficiency, and that increased free radical generation and decreased natural antioxidant may negatively affect wound healing and burn outcome in general. Targeting of these changes is considered an important strategy in the treatment of burns in an attempt to improve burn outcome in the clini...