ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...

stem cell based treatments are being increasingly explored for their possible potential to treat various cancers. mesenchymal stem cells believed to possess anti-tumor potential and are preferred for their properties like immune privileged nature, ability to migrate to the site of tumor and capability for multilineage differentiation. this tumor tropism property of mscs could be utilized to del...

background dietary factors such as intake of minerals may play a role in the etiology of esophageal cancer. although it has been hypothesized that manganese can affect the risk of some types ofcancer, its role in esophageal cancer is unknown. the objective of this study was to investigate the association between intakes of manganese with esophageal cancer in golestan cohort study. materials and...

background: breast cancer is the most common cancer and the leading cause of cancer death among the women worldwide. the risk of local and distant recurrence is the highest during the first two years following the initial treatment. very late relapse (after 12 years) is uncommon in breast cancer survivors. methods: herein, we report the characteristics and outcomes of 6 such cases of breast can...

Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle...

adiponectin is one of the most important members of adipokine family which is widely synthesized and secreted by adipose tissue. the action of adiponectin is via binding to main receptors. it has several actions including regulation of glucose level, lipid homeo­stasis and reproductive system. adiponectin can also influence vascular endothelium via preventing the migration of monocytes. the rol...

Background: Menstrual characteristics may serve as surrogate measures of endogenous estrogen and may be related to breast cancer risk. This case-control study investigated the relationship between menstrual factors and risk of breast cancer incidence in Iranian Center for Breast Cancer (ICBC). Materials and Methods: Forty seven Cases of breast cancer referred to ICBC and 77 controls were studie...