An unbounded number of events exist beneath the intricacy of each particular hematologic malignancy, prompting the tumor cells into an unrestrained proliferation and invasion. Aberrant expression of cyclin-dependent kinases (CDKs) is one of these events which disrupts regulation of cell cycle and subsequently, results in cancer progression. In this study, we surveyed the repressive impact of mu...

background: autoimmune type 1 diabetes mellitus is caused by t-cell mediated immune destruction of the insulin-producing β-cell in pancreatic islets of langerhans. specificity of the auto-antibodies and of the auto-reactive t-cells has been investigated, in which several auto-antigens were proposed. objective: to determine whether glutamic acid decarboxylase (gad) feeding would induce oral tole...

introduction: unlimited self renewal and potential capacity of embryonic stem cells (escs) in differentiating into a wide variety of cell types has made the cells an attractive source of donor cells for developmental studies and cell therapy. the aim of the present study was the evaluation of the transfection efficiency of pires2-egfp and pcdna3-hbdnf-v5 plasmids in cce es cells by the electrop...

based on experiments showing immunomodulatory effects of garlic (allium sativum l.), we sought to see whether allium hirtifolim boiss., belonging to the same genus of garlic, has any effect on immune responses. hydroalcoholic extract and polyphenolic fraction of a. hirtifolium bulbs were prepared. allicin (diallyl thiosulfinate), a biologically active component, was identified in plant bulbs by...

the leukocyte mi gration test (lht) in the prese nce of na t i v e igg, and l l e v amis ole were studi ed in 9 patients su f f e ring from cla s s i c a l r h e umatoid ar.thri t i s be f o r e a nd after treatment with l evamisole . fi f teen heal thy b l o od dono rs we r e s i mi l a r ly l nvestig ated a s cont r o ls . t- l ympho c yte s ub-popu lations (to ta l a nd active) a nd b-c el l...

thirty seven randomly selected patients suffering from multiple s c l e r os i s (ms) (17 males and 20 females)and 30 healthy control subjects were studied for the lymphocyte subpopulations and ce l l -medi a t e d immunity.we obs e r ved a decrease of the total t-cells and an increase of a ctive t-lymphocytes and b ce l l s , in ms p at i ent s as compared t o normal controls. the inability of...

cell-mediated immune (cmi) s t a t us and sub- popul at i ons o f pe r ipheral b l ood lymphocytes were investigated in one hundre d volunt a ry blood donors who were car r ier s of ag • he s a signi f i c ant decr e ase of t otal t-cells observed in hb ag carri e rs as compared t o normal controls. the percens t age o f active t-cells a nd b-lymphocytes did not d i f f e r signi f icant ly bet...

for demonstration of cell-mediated immunity and its role in the process of dermatophytosis, 98 patients with acute dermatophytosis (group i) and 131 chronic dermatophytosis patients (group 2) were chosen. in ail patients, lymphocyte transfonnation and skin test were used. 96 members of group i (98%) had positive delayed-type hypersensitivity (dth) responses to trichophytin, whereas only 43 subj...

objective(s): although tumor necrosis factor-related apoptosis-inducing ligand (trail) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (nsclc) exhibit trail-resistance. the purpose of this study was to determine whether subtoxic-dose cisplatin and trail could synergistically enhance apoptosis on nsclc cells and investigate its under...