Objective: GLUT4 is a type of glucose transporter and plays a central role in whole-body metabolism of carbohydrates. The muscle is the major site of GLUT4 and cell line models, to explore GLUT4 behaviors under new therapeutic approach, such as herbal components, should be evaluated. Here, C2C12 cell line is evaluated for GLUT4 translocation from intracellular compartment into the cell membrane...

Iron is essential to erythrocyte oxygen transport and is a catalyst for oxidative metabolism in all cells. Iron is absorbed by the duodenum and requires an acidic environment for optimal absorption. Iron is found for 70% in erythrocytes, and 30% in storage, and a small amount in myoglobin and cytochromes. Iron supplementation reduces anemia in breastfed infants and increases in significant dose...

statement of problem: glucocorticoid-induced osteoporosis is characterized by a decrease in osteoblast numbers and a marked impairment of new bone formation. purpose: the ain of present study was to evaluate the effect of methylprednisolone acetate on bone metabolism and bone mineral density in rats. materials and methods: eighteen male sprague dawley rats (8 weeks old, weighting 180 gm) were r...

b a ckground: previous studies have suggested that sex may be a factor influencing basal metabolic rate (bmr) in adults and school age children. however, few data are available about the effects of sex on bmr in pre-school children. in the present study, we investigated whether sex differences contribute to variations in bmr in pre-school age children. m et h o ds : measurements were made on th...

Introduction: Colorectal cancer (CRC) is the second leading cause of death in developed countries, mainly as a consequence metastatic spread. Secreted proteins are essential to communicate cells with tumor- microenvironment, favoring tumor progression and metastasis. The conditioned medium or cellular secretome, including exosomes, has demonstrated be rich source effectors biomarkers metastatiz...

Introduction: Sickle cell disease is the most common genetic in world, particularly sub-Saharan Africa. It a protean condition with multiple complications including disturbed iron metabolism. Objectives: To determine prevalence of metabolism abnormalities children homozygous sickle disease, to describe epidemiological, clinical and paraclinical characteristics these identify associated factors....

Aldosterone-producing adenomas (APAs) are characterized by aldosterone hypersecretion and deregulated adrenocortical cell growth. Increased energy consumption required to maintain cellular tumorigenic properties triggers metabolic alterations that shape the tumor microenvironment acquire necessary nutrients, yet our knowledge of this adaptation in APAs is limited. Here, we investigated cell-int...