نتایج جستجو برای: cerebral cortex methamphetamine neurotoxicity

تعداد نتایج: 292796  

Journal: :Behavioural brain research 2014
E Hensleigh L M Pritchard

Early life stress leads to several effects on neurological development, affecting health and well-being later in life. Instances of child abuse and neglect are associated with higher rates of depression, risk taking behavior, and an increased risk of drug abuse later in life. This study used repeated neonatal separation of rat pups as a model of early life stress. Rat pups were either handled a...

Journal: :NIDA research monograph 1996
L S Seiden K E Sabol

Methamphetamine and MDMA as well as similar substituted phenethylamines are toxic to DA and/or 5-HT neurons. The duration and magnitude of these effects are dose dependent and are accompanied by different degrees of recovery. MDMA-induced 5-HT damage persists for up to 52 weeks in the rat, and methamphetamine-induced DA damage persists for up to 3 years in the rhesus monkey. Several possible me...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
F Fumagalli R R Gainetdinov Y M Wang K J Valenzano G W Miller M G Caron

Methamphetamine (METH) is a powerful psychostimulant that is increasingly abused worldwide. Although it is commonly accepted that the dopaminergic system and oxidation of dopamine (DA) play pivotal roles in the neurotoxicity produced by this phenylethylamine, the primary source of DA responsible for this effect has remained elusive. In this study, we used mice heterozygous for vesicular monoami...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Paul S Fitzmaurice Junchao Tong Mehrdad Yazdanpanah Peter P Liu Kathryn S Kalasinsky Stephen J Kish

Animal studies suggest that the widely used psychostimulant drug methamphetamine (MA) can harm brain dopamine neurones, possibly by causing oxidative damage. However, evidence of oxidative damage in brain of human MA users is lacking. We tested the hypothesis that levels of two "gold standard" products generated from lipid peroxidation, 4-hydroxynonenal (one of the most reactive lipid peroxidat...

Today, neuroscientists are interested in discovering human brain functions through brain networks. In this regard, the evaluation of dynamic changes in functional connectivity of the brain regions by using functional magnetic resonance imaging data has attracted their attention. In this paper, we focus on two model-based approaches, called the exponential weighted moving average model and the d...

Journal: :Turkish neurosurgery 2013
Bulent Bakar Emine Arzu Kose Mahi Balci Pinar Atasoy Bahram Sarkarati Aslihan Alhan Kamer Kilinc Ismail Semih Keskil

AIM Although polyethylene glycol (PEG) is a neutral, biocompatible hydrophilic polymer recognized for its lack of interaction with biological barrier, its neurotoxicity has not been clearly identified in neurosurgery. This study is constructed to evaluate the possible neurotoxicity of a PEG hydrogel dural sealant. MATERIAL AND METHODS After a burrhole was opened in the left pa...

Journal: :The Journal of pharmacology and experimental therapeutics 1986
P K Sonsalla J W Gibb G R Hanson

Previous studies have demonstrated that the effects of methamphetamine (METH) on dopaminergic and serotonergic systems are likely related to METH-induced increases in dopamine release. The ability of haloperidol to prevent these effects of METH suggests that dopamine receptor activation is involved in mediating these METH actions. The present studies were undertaken to determine what role the d...

Journal: :Neuroscience letters 2005
Yasushi Ishida Keiichi Kawai Yasuhiro Magata Hiroshi Abe Mitsuyoshi Yoshimoto Ryuichiro Takeda Hiroyuki Hashiguchi Takahiro Mukai Hideo Saji

We studied the positron emission tomography (PET) tracer distributions of ligands for dopamine D1 receptors ([11C]SCH23390) and D2 receptors ([11C]raclopride) and of the dopamine precursor analog 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine ([18F]FDOPA) in the brain after 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle in rats. The number of methamphetamine-induced rotation was ...

Journal: :Stroke 2002
Xiaoying Wang Tatsuro Mori Toshihisa Sumii Eng H Lo

BACKGROUND AND PURPOSE Apoptotic-like pathways may contribute to brain cell death after intracerebral hemorrhage. In this study, we used a simplified in vitro model of hemoglobin neurotoxicity to map the caspase cascades involved and to document the role of oxidative stress. METHODS Primary neuronal cultures were obtained from rat cerebral cortex and exposed to hemoglobin to induce cell death...

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