A global optimization algorithm i s introduced which generalizes Kushner’s univariate search [1]. It aims to minimize the number o f probes (function evaluations) required for a g i v e n confidence in the results. All known p r o b e s contribute to a stochastic model of the underly ing “score surface”; this model is interrogated for the location most likely to exceed the current result goal. ...

Defining a relation for equilibrium pressure in a porous medium has been difficult to do in terms of readily measurable parameters. We present a simplified analysis of this problem using the first law of thermodynamics combined with a fractal description of a porous system. The results show that the variation in fluid interfacial area with fluid volume, and the respective interfacial surface te...

In this work, a solid phase spectrophotometric method in association with flow injection analysis for formaldehyde determination has been developed with direct measurement of light-absorption in C(18) material. The 3,5-diacetyl-1,4-dihydrolutidine produced from the reaction between formaldehyde and fluoral P was quantitatively retained on C(18) support and the spectrophotometric detection was p...

Halophilic and halotolerant microorganisms are good candidates for decolorization of azo dyeswhich are routinely used in the dyeing process in textile industries. In this paper, theoptimization of biological decolorization of synthetic dye solutions containing Remazol Black Bby the previously isolated halophilic bacterium Halomonas sp. D2 is investigated. In a primaryinvestigation using a one-f...

Fractal is a component model developed initially by France Telecom and INRIA and later as an open source project in the ObjectWeb consortium. The component model is defined by the Fractal Component Model specification [BCS]. The specification defines a hierarchical component model, where a component is specified in terms of its server and client (provided and required) interfaces and configurab...

Signaling through the second messenger cyclic di-GMP (c-di-GMP) is central to the life cycle of Vibrio cholerae. However, relatively little is known about the signaling mechanism, including the specific external stimuli that regulate c-di-GMP concentration. Here, we show that the phosphate responsive regulator PhoB regulates an operon, acgAB, which encodes c-di-GMP metabolic enzymes. We show th...

Abstract Background Infliximab (IFX), a monoclonal antibody approved for treating Crohn’s disease (CD), is known to show differing drug clearances in patients according several clinical factors. However, information on the population pharmacokinetics (PKs) of intravenous (IV) IFX lacking Korean with CD. Therefore, this study, we aimed establish PK model IV population. Methods We retrospectively...

Fractals can model many classes of time-seri" data. The fractal dimension is an important actertsfic of ftaqo& that coniai, c information . out their geometrical structure at multiple Ntod re a b g ms i l d h ti BC m h d t c s, : s a ass of CJJ4 ent proac ox-coun n ( } et over 1 g c es, e.g., o , o estimate the fractal-dimension. Jr. this paper, the d rential box-counting (DBC) approach, origin...