OBJECTIVE The aim of this study was to explore the genetic association of cyclooxygenase-2 (COX2) gene promoter region polymorphisms with Parkinson's disease (PD) susceptibility in Chinese Han population. METHODS The genotyping of COX2 gene polymorphisms was conducted by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 122 patients with PD and 120 healthy perso...

Using zebrafish embryos, we reported that 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD) evoked circulation failure through activation of the aryl hydrocarbon receptor type 2 (AHR2). However, the following molecular target after AHR2 activation is largely unclear. It has been reported that TCDD induces cyclooxygenase 2 (COX2), a rate-limiting enzyme for prostaglandin synthesis in some cells. In this...

Nuclear factor of activated T-cells (NFAT) and NF-kB pathway associated processes are involved in the pathogenesis of various inflammatory disorders, for example, periodontal disease. The activation of these pathways is controlled by the regulator of calcineurin 1 (RCAN1). The aim of this study was to elucidate the role of RCAN1 in periodontal disease. Healthy and inflamed periodontal tissues w...

Medicinal herb Bauhinia variegata L. is the main ingredient in “Gandmala Kandan Ras” herbomineral medicine used Ayurveda for treatment of swelling, inflammation and tumors. This study aimed to isolate anti-inflammatory compounds from methanolic extract aerial parts variegata. Through bioassay-guided isolation, three known flavonoids, namely kaempferol, ombuin quercetin were identified variega. ...

Megabalanus coccopoma (Darwin, 1854) is a globally invasive species in Balanomorpha (Crustacea). This model organism for studying marine pollution and ecology. However, its mitogenome remains unknown. The sequencing of M. completed the present study. It has 15,098 bp length, including 13 protein-coding genes (PCGs), 2 ribosomal RNAs (rRNAs), 22 transfer (tRNAs), along with putative regulatory a...

BACKGROUND The understanding of the cellular responses implicated in perinatal brain damages and the characterization of the various mechanisms involved might open new horizons for understanding the time of onset of a brain hypoxic-ischemic lesion and for effective therapeutic strategies. METHODS We performed an immunohistochemical investigation on brain and brainstem sections of 47 peripartu...

Sco1 and Sco2 are mitochondrial copper-binding proteins involved in the biogenesis of the Cu(A) site in the cytochrome c oxidase (CcO) subunit Cox2 and in the maintenance of cellular copper homeostasis. Human Surf1 is a CcO assembly factor with an important but poorly characterized role in CcO biogenesis. Here, we analyzed the impact on CcO assembly and tissue copper levels of a G132S mutation ...

BACKGROUND Several studies have recently indicated the prognostic or predictive role of several biomarkers in colorectal cancer. We sought to investigate the prognostic value of prostaglandin synthase 2 (PTGS2), cyclooxygenase 2 (COX2), thymidylate synthetase (TYMS), thymidine phosphorylase (TYMP), dihydropyrimidine dehydrogenase (DPYD) and topoisomerase I (TOPO1) in colorectal cancer patients ...