Drug delivery across the skin is used for several millennia to ease gastrointestinal (GI) ailments in Traditional Persian Medicine (TPM). TPM topical remedies are generally being applied on the stomach, lower abdomen, lower back and liver to alleviate GI illnesses such as dyspepsia, gastritis, GI ulcers, inflammatory bowel disease, intestinal worms and infections. The aim of the present study i...

Crocin biosynthesis in Crocus has been proposed to proceed through a zeaxanthin cleavage pathway catalyzed by carotenoid cleavage dioxygenase 2 (CCD2), and followed by glucosylation reactions catalyzed by CsGT2 (UGT74AD1). In Crocus ancyrensis flowers, crocins with eight (crocin-1), seven (crocin-2), and six glucose (crocin-3) moieties accumulated both in stigma and tepals. We have characterize...

drug delivery across the skin is used for several millennia to ease gastrointestinal (gi) ailments in traditional persian medicine (tpm). tpm topical remedies are generally being applied on the stomach, lower abdomen, lower back and liver to alleviate gi illnesses such as dyspepsia, gastritis, gi ulcers, inflammatory bowel disease, intestinal worms and infections. the aim of the present study i...

saffron (crocus sativus l.) is an indigenous and the most valuable and marginal plant in iran. however, limited knowledge exists on its molecular biology. the importance of this plant is due to the color, flavor and medicinal properties of its red stigmas. saffron stigmas contain a high amount of carotenoids such as crocetin and crocin. two genes, bch and pds, have essential role in carotenoid ...

Alzheimer’s disease (AD) is a neurodegenerative disease and the leading cause of dementia worldwide. Epidemiological studies support the important role of diet in prevention and improvement of AD. In Traditional Persian Medicine (TPM), there is multiple dietary guidelines to prevent and alleviate dementia and memory impairment. Pharmacological studies have been shown that most of the TPM-recomm...

Objective(s): Crocus sativus (saffron) has been widely used in traditional medicine. It has also been found to possess many beneficial properties in modern medicine. The most important ingredients of saffron are crocin, crocetin, safranal, and picrocrocin. This study evaluated the protective effects of crocin against the inflammation, oxidative stress, and functional disturbances of the kidney ...

Apo-retinal-binding protein (apo-RBP) from human plasma was found to bind all-trans-3-dehydroretinol and to protect the chromophore from degradation. The all-trans-3dehydroretinol-RBP complex, in turn, binds tightly to prealbumin at physiological ionic strength as judged by gel filtration chromatography. All trans 3 dehydroretinal also formed a complex with RBP but this complex did not bind to ...