BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and is up-regulated in biliary tract cancer (BTC), contributing to aggressive clinical features. In this study we investigated the cytotoxic effects of PTC-209, a recently developed inhibitor of BMI1, in BTC cells. PTC-209 reduced overall viability in BTC cell lines in a dose-dependent fashion (0.04 - 20 µM). Treatment with PT...

Gemcitabine and cisplatin combination therapy (GC) is accepted as a standard treatment for advanced biliary tract cancer (BTC). However, little information is available regarding such treatment in the clinical practice setting in Japan. We retrospectively examined the clinical data of patients with unresectable or recurrent BTC who received GC as first-line treatment. The regimen consisted of c...

In this contribution the performance of Reed-Solomon (RS) Block Turbo Coding (BTC) is studied in a 16-QAM modulated OFDM system when operating on a Rayleigh fading channel. BER and PER performances are shown and compared to the performance of Convolutional Turbo Coding (CTC). BTC proves to mitigate the irreducible error floor that limits the performance of CTC at high signal-to-noise ratios (SNR).

Although surgical resection is the only way to cure biliary tract cancer (BTC), most BTCs are unresectable by the time they are diagnosed. Chemotherapy is usually used to treat unresectable BTC, but its impact on survival is small. Here, we report the case of a 70-year-old woman with a locally advanced intrahepatic cholangiocarcinoma that was initially diagnosed as an unresectable liver metasta...

This paper presents a new application of a well-studied image coding technique, namely block truncation coding (BTC). It is shown that BTC can not only be used for compressing color images, it can also be conveniently used for content-based image retrieval from image databases. From the BTC compressed stream (without performing decoding), we derive two image content description features, one te...

The asymmetric unit of the title rare earth coordination polymer, [Ce(C(9)H(3)O(6))(C(3)H(7)NO)(2)](n), contains one eight-coordinated Ce(3+) ion, one benzene-1,3,5-tricarboxyl-ate (BTC) ligand and two coordinated N,N-dimethyl-formamide (DMF) mol-ecules. The Ce(3+) ion is coordinated by six O atoms from four carboxyl-ate groups of the BTC ligands and by two O atoms from two terminal DMF mol-ecu...

Adenocarcinomas of the gallbladder (GBC) and bile ducts (cholangiocarcinoma) (combined as biliary tract cancers, BTC) are uncommon tumors in the United States, but are endemic in parts of South America and Asia. BTC are aggressive tumors with poor survival. Published response rates to chemotherapy are less than 30% and no survival benefit has been demonstrated from palliative systemic therapy. ...

—In this paper, we demonstrate the higher hardware ef ciency of Reed-Solomon (RS) parallel turbo decoding compared with BCH parallel turbo decoding. Based on an innovative architecture, this is the rst implementation of fully parallel RS turbo decoder. A performance analysis is performed showing that RS Block Turbo Codes (RS-BTC) have decoding performance equivalent to Bose Ray-Chaudhuri Hocque...