Dipyrido[3,2-a :2',3'-c]phenazine (dppz) derivatives were conjugated to 9-mer and 18-mer DNA (ODN) at a site without nucleobase, either at the 5'or 3'-end or at a internucleotide position, via linkers of 7, 12, or 18 atoms lengths. These dppz-linked ODNs were synthesized using novel backbone glycerol phosphoramidites: Glycerol, serving as artificial nucleoside without nucleobase, was modified t...

Free drug serum concentrations of minocycline associated with the doses given to humans (100 mg every 12 hours for 24 hours) were simulated in an in vitro hollow-fiber pharmacokinetic model. Four strains of methicillin (meticillin)-resistant Staphylococcus aureus (MRSA), United Kingdom EMRSA 15 and 16 plus a pair of blood culture isolates before and after long-term minocycline treatment, were e...

BACKGROUND Mycoplasma hyopneumoniae (M. hyopneumoniae) is the primary agent of enzootic pneumonia in pigs. Pigs are often infected with different M. hyopneumoniae strains. This study assessed the efficacy of vaccination against experimental infection with two genetically different M. hyopneumoniae strains in weaned piglets. At 33 days of age (D0), 45 M. hyopneumoniae-free piglets were randomly ...

Saccharomyces cerevisiae is a supplement option for ruminants due to its ability stimulate the immune system and productivity; however, there are few studies that demonstrate effectiveness of this yeast in dairy cattle, especially regarding effect on milk phagocyte function. Thus, study examined two presentations autolyzed S. function production healthy Holstein cows from third fifth months lac...

The purpose of this study is to identify areas energy-efficient development in petrochemical supply chains through the use computer analysis tools. uses system approach methods, comparisons, vertical dynamic analysis, economic and mathematical modeling, forecasting, factor analysis. Listed implementation methods helps meet number scientific results: systematized programs are applicable for prod...

Immunotherapy with tumor-infiltrating lymphocytes (TIL) or oncolytic adenoviruses, have shown promising results in cancer treatment, when used as separate therapies. When combination, the antitumor effect is synergistically potentiated due adenovirus infection and its immune stimulating effects on T cells. Indeed, studies hamsters a 100% complete response rate animals were treated coding for TN...

this study has investigated the long-run and short-run effects of relative productivity on real exchange rate using annual time series data of iran and its major trade partners over the period 1980-2005. to analyze such effect which refers to the balassa-samuelson effect, this research uses auto-regressive distributed lags (ardl) method, to deal with dynamics of the relationship between product...

firm size and its impact on the firm performance examined in all of economics historical periods from different point of view. meanwhile, productivity is one the most important performance index for each firm, therefore so many studies tries to survey firm size impact on it. in iran also, economics literature replete with productivity studies but the impact of size on it rarely seen between the...