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1689 www.drugdiscoverytoday.com The first attempts at global analysis of gene expression were undertaken in the mid-1970s with studies of the hybridization of an mRNA pool with radioactively labeled cDNA. Interest in gene expression increased steadily during the 1980s, and in the 1990s a new era of high throughput gene expression studies unfolded with the development of microarrays [1,2]. Altho...
Feeding regulation involves multiple peripheral and brain mechanisms (12). Chemical signaling is a pivotal mechanism. One class of endogenous feeding-regulatory substances is represented by cytokines. In this article, various issues of feeding inhibition by cytokines are discussed, including behavioral, cellular, and molecular mechanisms. The description will focus on data obtained with interle...
Zeng, Ningxin, Christoph Athmann, Tao Kang, John H. Walsh, and George Sachs. Role of neuropeptidesensitive L-type Ca21 channels in histamine release in gastric enterochromaffin-like cells. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G1268–G1280, 1999.—Peptides release histamine from enterochromaffin-like (ECL) cells because of elevation of intracellular Ca21 concentration ([Ca]i) by ...
Eads, Brian D., and Steven C. Hand. Regulatory features of transcription in isolated mitochondria from Artemia franciscana embryos. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1588–R1597, 1999.—Optimal conditions were developed for an in organello transcriptional run-on assay using mitochondria isolated from Artemia franciscana embryos to investigate potential regulatory fe...
Heunks, Leo M. A., Jose Viña, Cees L. A. Van Herwaarden, Hans T. M. Folgering, Amparo Gimeno, and P. N. Richard Dekhuijzen. Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1697–R1704, 1999.—In the present study, we hypothesized that exhaustive exercise in patients with ch...
Thomas-Delloye, Véronique, Florence Marmonier, Claude Duchamp, Béatrice Pichon-Georges, Joël Lachuer, Hervé Barré, and Gabriel Crouzoulon. Biochemical and functional evidences for a GLUT-4 homologous protein in avian skeletal muscle. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1733–R1740, 1999.—The characteristics and modulation of glucose transport were investigated in ske...
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