We investigated the relationship between protein and tryptophan intake and the adverse-effect-level of di(2-ethylhexyl)phthalate (DEHP). Growth retardation of young rats due to DEHP was strengthened by increasing protein level. The addition of tryptophan to the diet caused extreme increases in the nicotinamide formation, but no growth retardation was observed.

Phthalate esters such as di(2-ethylhexyl)phthalate (DEHP) either promote or inhibit rat liver tumorigenesis depending on the carcinogenesis protocol. In this study, we examined the expression of two histochemical markers, the tumor associated isozyme of aldehyde dehydrogenase (ALDH-3) and the oncoprotein p21 Ras, in the livers of male F344 rats. The rats were initiated with DEN and further trea...

The human constitutive androstane receptor (CAR, CAR1) regulates the expression of genes involved in xenobiotic metabolism in the liver. The CAR gene uses multiple alternative splicing events during pre-mRNA processing, thereby enhancing the CAR transcriptome. Previous reports have identified two prominent human CAR variants, CAR2 and CAR3, that possess fourand five-amino acid insertions in the...

A reversed-phase gradient elution, UV detection method is developed for the simultaneous determination of mono (2-ethylhexyl) phthalate [MEHP] and di (2-ethylhexyl) phthalate [DEHP] in tissue samples. The method is validated with respect to extraction recovery, inter and intra-day precision, linearity of response, detect ability, and specificity. The validated method has been successfully appli...

Phthalates are additives or plasticizers added to make plastics soft. However, they could leach into the environment and cause harm human health when contacted. Sites along Ekpan river have been used for open dumping of refuse. The also serves as a point source disposal effluents from Warri Refinery Petrochemical Company Limited (WRPC). Hence, need preliminary study phthalates across system. Su...

Phthalates are organic contaminants that used as plasticizers in many plastic food packaging materials. Because of their lipophilic character, oils the primary source human exposure to phthalates. In this study, presence five phthalate esters; diethylhexyl (DEHP), dibutyl (DBP), butyl benzyl (BBP), diisononyl (DINP) and diisodecyl (DIDP) olive flavored with different materials marketed Turkey 2...