Objective(s):Development of new generation of vaccines against leishmaniasis is possible because long-term protection is usually seen after recovery from cutaneous leishmaniasis. ISCOMATRIX is particulate antigen delivery system composed of antigen, cholesterol, phospholipid and saponin. In this study, the role of ISCOMATRIX bilayer composition made by different phase transition temperature (Tc...

Many Gram-negative pathogens encode type 3 secretion systems, sophisticated nanomachines that deliver proteins directly into the cytoplasm of mammalian cells. These systems present attractive opportunities for therapeutic protein delivery applications; however, their utility has been limited by their inherent pathogenicity. Here, we report the reengineering of a laboratory strain of Escherichia...

PURPOSE To describe the anesthetic management of a parturient with Ehlers Danlos syndrome (EDS) type IV. CLINICAL FEATURES A 29-yr-old pregnant woman with EDS type IV was seen in the Obstetric Anesthesia Pre-assessment Clinic at 30 weeks gestation. She had a history of vertebral artery dissection, resulting in a transient neurological deficit at 22 yr of age. She had a normal vaginal delivery...

Status of this Memo This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the "Internet Official Protocol Standards" (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. Abstract The Multipart/Report Multipurpos...

A 40-year-old patient with Type I Von Willebrand Disease presented for elective cesarean section. At the operating theater before delivery, while receiving cryoprecipitate, she developed an anaphylactic reaction requiring resuscitation. Once was hemodynamically stable, factor VIII/VWF concentrates were administered and operative delivery performed, a good maternal fetal outcome.

The Multipart/Report MIME content-type is a general "family" or "container" type for electronic mail reports of any kind. Although this memo defines only the use of the Multipart/Report content-type with respect to delivery status reports, mail processing programs will benefit if a single content-type is used to for all kinds of reports. This document is part of a four document set describing t...

this study aims to investigate the capability of forming itraconazole containing niosomes with span 60 and brij 58 as non-ionic surfactants. lower cost and higher stability makes niosomes a more suitable choice in comparison with liposomes.the capability to form vesicles as an itraconazole delivery system and the influence of different factors such as type of surfactant and molar ratio of chole...

Targeted Protein Deliveries In article number 2204620, Hak-Sung Kim and co-workers develop a new type of protein self-assembly using human clathrin for targeted delivery. A redesigned triskelion is dual-functionalized with functional biomolecules. The resulting assembly exhibits significantly high avidity an efficient delivery cargo into tumor cells.

BACKGROUND Gestational diabetes mellitus (GDM) occurs in 3-5% of all pregnancies. GDM increases both maternal and fetal risks, causes fetal macrosomia, and hence increases the rates of caesarean sections and delivery complications such as shoulder dystocia. An early predictive marker and consequent early treatment could be beneficial, so amniotic fluid insulin and C-peptide have been examined i...