The purpose of the current review is to bring up date some studies and data about effects hypoglycemic oral drugs in combination with DPP-4 inhibitors. As medicine pharmaceutical industry are revolutionary type 2 diabetes protocols, scientists made a close research on patients that have combined metformin plus sulfonyurea Statistics showed sulfonylurea compared inhibitors, metformin, increased ...

Metallo-β-lactamases (MβL) catalyzing the hydrolytic cleavage of the four-membered β-lactam ring in broad spectrum of antibiotics and therefore inactivating the drug; However, the mechanism of these enzymes is still not well understood. Electronic structure and electronic energy of metallo-β-lactamase active center, two inhibitors of this enzyme including penicillin and cephalexin, and differen...

Molecular modeling is a set of computational techniques for construction of 3D structure of a protein especially membrane bound proteins whose structures can not be elucidated using experimental techniques. These techniques has been applied in the study of membrane metalloproteases for comparing wild and mutated enzymes, docking inhibitors in the catalytic site and examination of binding pocket...

Human papillomaviruses (HPV) are a group of strong human carcinogen viruses considered to be the fourth leading cause of mortality among women in the world. HPV is the most important cause of cervical cancer, which is the second most common cancer in women living in low and middle-income countries. To date, there is no effective cure for an ongoing HPV infection; therefore, it is required to in...

6. Dolcetti R, Doglioni C, Maestro R et al. P53 over-expression is an early event in the development of human squamous-cell carcinoma of the larynx: Genetic and prognostic implications. Int J Cancer 1992; 52(2): 178-1 82. 7. Calitano J, van der Riet P, Westra W at al. Genetic progression model forhead and neck cancer: Implications for field cancerization. Cancer Res 1996; 56: 2488-2492. 8. El-D...

Bakground: Aspergillus fumigatus is an airborne opportunistic fungal pathogen that can cause fatal infections in immunocompromised patients. Although the current anti-fungal therapies are relatively efficient, some issues such as drug toxicity, drug interactions, and the emergence of drug-resistant fungi have promoted the intense research toward finding the novel drug targets. Methods: In searc...

Arthritis refers to different medical conditions associated with disorder of the primary structures that determine joint functions such as bones, cartilage and synovial membranes. Drug discovery and delivery to retard the degeneration of joint tissues are challenging. Current treatments of different arthritis involves administration of ideal non-steroidal anti-inflammatory drugs (NSAIDs) but ar...