The current study involves the fabrication of oral bioadhesive bilayer matrices of narrow absorption window drug baclofen and the optimisation of their in vitro drug release and characterisation. Statistical design of experiments, a computer-aided optimisation technique, was used to identify critical factors, their interactions and ideal process conditions that accomplish the targeted response(...

A reversed-phase high-performance liquid chromatographic method for separation of the enantiomers of ketoprofen in formulations and in plasma matrices has been developed and optimized. A central composite design was used to develop response models and Derringer’s desirability function was then used for simultaneous optimization of chiral resolution and analysis time. This procedure enabled disc...

Taguchi method was known as an off-line quality control methodology to be used in many industries. Until now, most applications only focus on optimizing a single-response in a static system. Furthermore, due to the increasing complexity of the product design, more than one quality characteristic must be considered simultaneously to improve the production quality. Therefore, there are several st...

Applying parameter design to a system that has a binary-type performance, an efficient metric is to employ the operating window (OW) which is the range between two performance limit thresholds. Paper feeder design is a typical problem of the OW method. The wider OW, the higher performance of the system is. This study uses an approach based on artificial neural networks (ANN) and desirability fu...

Abstract The purpose of this study is to explore the direct and interaction effects entrepreneurial events (feasibility desirability) perceived risk (opportunity threat) on intention in a transitional economy – Vietnam. testing results show that desirability feasibility have interactive entrepreneur intention. Risk as both threat opportunity has moderating