نتایج جستجو برای: diagnosis of knowledge 0201
تعداد نتایج: 21220223 فیلتر نتایج به سال:
Heat shock proteins (hsp) 96 play an essential role in protein metabolism and exert stimulatory activities on innate and adaptive immunity. Vaccination with tumor-derived hsp96 induces CD8(+) T cell-mediated tumor regressions in different animal models. In this study, we show that hsp96 purified from human melanoma or colon carcinoma activate tumor- and Ag-specific T cells in vitro and expand t...
Although CD8(+) T cells help control Mycobacterium tuberculosis infection, their M. tuberculosis Ag repertoire, in vivo frequency, and functionality in human tuberculosis (TB) remains largely undefined. We have performed genome-based bioinformatics searches to identify new M. tuberculosis epitopes presented by major HLA class I supertypes A2, A3, and B7 (covering 80% of the human population). A...
A potent anti-human (hu) p53 CD8+ CTL response develops in HLA A*0201 transgenic (Tg) mice after immunization with peptides corresponding to HLA A*0201 motifs from hu p53. Mice immunized with the hu P53(149-157) peptide develop a CTL response that is of moderately high affinity and is capable of recognizing hu tumor cells expressing mutated p53. In this report, the mRNAs encoding the predominan...
ABSTRACT Pharyngitis is one of the most common bacterial diseases. Its dangerous complications such as rheumatic fever and glomerulonephritis increase the importance of diagnosis and treatment. In order to determine mothers knowledge about symptoms, prevention, therapeutic care and complications of pharyngitis, this survey was carried out on 508 urban and 80 rural mothers in Kerman in summer ...
A diagnostic framework in which there is a clear separation between the expertise per se and relevant background knowledge is discussed. We argue for the need to have an explicit representation of background knowledge. Background knowledge is domain foundational knowledge or common-sense knowledge; it is brought into play in the diagnostic context activated by the foreground knowledge, the diag...
Background and Aim: Breast cancer is the most common type of cancer among women in most countries of the world. One of the most important diagnostic measures for early diagnosis is breast self-examination (B.S.E.). The present study aimed at determining the effect of health training on knowledge, attitude, and practice of female teachers in Yazd intermediate schools on breast cancer. Materials...
BACKGROUND The aim of this study was to explore the correlation of gene polymorphisms of human leukocyte antigen-DQB1 (HLA-DQB1) with the infection outcome and replication status of hepatitis B virus (HBV) positive patients in the Xinjiang Uygur population in China. METHODS 110 cases of chronic hepatitis B (CHB) of Xinjiang Uygur were examined clinically, which were named as the CHB group; 10...
Hantaan virus (HTNV) infections can cause severe hemorrhagic fever with renal syndrome (HFRS) in humans, which is associated with high fatality rates. Cytotoxic T cell (CTL) responses contribute to virus elimination; however, to date, HLA class I allele-restricted HTNV glycoprotein (GP) epitopes recognized by CTLs have not been reported, limiting our understanding of CTL responses against HTNV ...
PURPOSE Telomerase is an attractive target antigen for cancer immunotherapies because it is expressed in >85% of human tumors but is rarely found in normal tissues. A HLA-A*0201-restricted T-cell epitope was previously identified within telomerase reverse transcriptase hTERT:540-548. This peptide was reported to induce CTL that recognized tumor cells and transfectants that endogenously expresse...
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