A wvhite shoe salesman first entered University Hospitals of Cleveland at age 61 stating that he had been rejected from the armed services 23 years previously and that 21 years ago life insurance had been refused because of a heart murmur. He denied having rheumatic fever or other febrile illnesses. His only memory of trauma was being thrown over the handlebars of his bicycle at age 12. From ag...

After the report that there was no statistical significance in the general mortality of the DIG study, the indication of digoxin in the treatment regimens for congestive heart failure (CHF) drastically decreased. Post hoc studies that reassessed the DIG study data, indicated that an aspect that was not considered in this multicenter study has a critical influence on the prognosis of patients: t...

The use of digitalis preparations dates to the 1500s. However, it was not until the late 1700s that Withering recognized that such compounds elicited an effect on the heart. By 1790, the cardiac effects of digitalis were labeled as their primary mode of action.' Digitalis compounds continue to be popularly employed for therapeutic control of various cardiac ailments. The term digitalis is used ...