c a anagement of vesicoureteral reflux (VUR) involves as uch controversy as management of prostate cancer. magine if there was an easily available serum or radioraphic test that could definitively determine whether a an with prostate cancer would have any local spread of he disease, and whether it would ever cause any sympoms. Would not that test replace prostate-specific antien (PSA) or any ot...

Individuals with Down syndrome are predisposed to show a specific behavioural phenotype, or a pattern of strengths and challenges in functioning across different domains of development. It is argued that a developmental approach to researching the Down syndrome behavioural phenotype, including an examination of the dynamic process of the unfolding of the phenotype, will advance science and serv...

A major objection to top-down accounts of lexical recognition has been that they are incompatible with an account of acquisition, it being argued that bottom-up segmentation must precede lexical acquisition. We counter this objection by presenting a top-down account of lexical acquisition. This is made possible by the adoption of a flexible criterion as to what may constitute a lexical item dur...

One of the defining features of the field of robotics is its breadth and heterogeneity. Unfortunately, despite the availability of several robotics middleware services, robotics software still fails to smoothly handle at least two kinds of variability: algorithmic variability and lower-level variability. The consequence is that implementations of algorithms are hard to understand and impacted b...

Hyperuniformity characterizes a state of matter that is poised at a critical point at which density or volume-fraction fluctuations are anomalously suppressed at infinite wavelengths. Recently, much attention has been given to the link between strict jamming (mechanical rigidity) and (effective or exact) hyperuniformity in frictionless hard-particle packings. However, in doing so, one must nece...

In this issue, Limpitikul et al used the novel CRISPR interference (CRSPRi) strategy to suppress the expression of an arrhythmogenic mutant calmodulin (CaM) gene in human induced pluripotent cell-derived cardiomyocytes (iPSC-CM). This mutant CaM (D130G) is linked with long-QT syndrome (LQTS). The main LQTS mechanism is via a loss in Ca affinity of CaM, resulting in a loss of Ca-dependent inacti...

Most speaker diarization systems fit into one of two categories: bottom-up or top-down. Bottom-up systems are the most popular but can sometimes suffer from instability from merging and stopping criteria difficulties. Top-down systems deliver competitive results but are particularly prone to poor model initialization which often leads to large variations in performance. This paper presents a ne...

This paper considers the pricing and hedging of collateralized debt obligations (CDOs). CDOs are complex derivatives on a pool of credits which we choose to analyse in the top down model proposed in Filipović et al. [4]. We reflect on the implied forward rates and bring them in connection with the top-down framework in Lipton and Shelton [8] and Schönbucher [11]. Moreover, we derive variance-mi...

Association Rule mining is one of the important and most popular data mining techniques. It extracts interesting correlations, frequent patterns and associations among sets of items in the transaction databases or other data repositories. Apriori algorithm is an influential algorithm for mining frequent itemsets for Boolean association rules. Firstly, the concept of association rules is introdu...

System-level design methodologies have been introduced as a solution to handle the design complexity of mixed Hardware / Software systems. In this paper we describe a system-level design flow starting from Simulink specification, focusing on concurrent hardware and software design and verification at four different abstraction levels: System Simulink model, Transaction Simulink model, Macro arc...