In their Point of View entitled "Experimental Allergic Encephalomyelitis: A Misleading Model of Multiple Sclerosis," Sriram and Steiner(1) wrote, "The most disappointing aspect of EAE [experimental allergic encephalomyelitis] as a potential model for MS is its almost total inability to point toward a meaningful therapy or therapeutic approach for MS." Actually, EAE has led directly to the devel...

1 Department of Neurosciences, Centre de recherche du CHU de Québec – Université Laval, Quebec City, QC, Canada, 2 Department of Molecular Medicine, Université Laval, Quebec City, QC, Canada, 3 Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 4 Department of Neurosciences, Université de Montréal and CRCHUM, Montréal, Q...

The ubiquitin ligase Peli1 has previously been suggested as a potential treatment target in multiple sclerosis. In the multiple sclerosis disease model, experimental autoimmune encephalomyelitis, Peli1 knock-out led to less activated microglia and less inflammation in the central nervous system. Despite being important in microglia, Peli1 expression has also been detected in glial and neuronal ...

multiple sclerosis (ms) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. ionic conductances regulate t cell activation as well as neuronal function and thus have been found to play a crucial role in ms pathogenesis. since present therapeutical approaches are only parti...

objective(s): multiple sclerosis (ms) is known as a progressive inflammatory cns disease. cytokines belong to th1 or th2 family and inflammatory cells, play significant role in pathophysiology of ms. thus, any treatment supposed to influence the relation between th1 to th2 cytokines expression. although vitamin d has been prescribed as a therapeutic supplement of ms for a long time, it is not c...

T cell vaccination (TCV) is a method to induce resistance to autoimmune diseases by priming the immune system with autoreactive T cells. This priming evokes an anti-idiotypic regulatory T cell response to the receptors on the autoreactive T cells. Hence resistance is induced. To prevent the inoculated autoreactive cells from inducing autoimmunity, cells are given in a subpathogenic dose or in a...