objective: hexavalent chromium [cr (vi)] compounds are well-known environmental contaminants  generated from industrial processes. several studies have reported the harmful effects of cr (vi) on different organs, however, little is known about neurotoxic effects of cr (vi). the aim of this study is to investigate the toxic effects of cr (vi) on pc12 cells. methods: pc12 cells were cultured foll...

The intracellular concentrations of sodium, chloride, phosphorus and potassium under normal conditions in pavement epithelial (PE) cells of brown trout (Salmo trutta) gill were 66, 51, 87 and 88 mmol l-1 respectively. The concentrations of these elements under identical conditions in mitochondria-rich (MR) cells were not significantly different, except for that of chlorine, which was lower in M...

Determining mechanism-based biomarkers that distinguish adaptive and adverse cellular processes is critical to understanding the health effects of environmental exposures. Shifting from in vivo, low-throughput toxicity studies to high-throughput screening (HTS) paradigms and risk assessment based on in vitro and in silico testing requires utilizing toxicity pathway information to distinguish ad...

The optimization of biomaterials’ biodegradation rate similar to tissue regeneration, is one of the main goals of tissue engineering. However, the necessity to assess their possible toxicity is always considered. The aim of this study was cytotoxicity and genotoxicity evaluation of fluorapatite/bioactive glass (FA/BG) nanocomposite foams with two various weight ratios to determine the optimal c...

background: the concentrations and distributions of natural and anthropogenic radioactive materials in soils of the site of rooppur nuclear power plant (rnpp) were investigated with the aim of evaluating the environmental radioactivity and radiation hazard. materials and methods: soil samples were collected from 40 locations in and around the proposed site of rooppur power plant and determined ...

Introduction: The present study investigated the relatively high concentrations of natural radionuclides in raw material that used in ceramic manufacturing, and estimated the occupational exposure due to these activity concentrations. Material and Methods: A high-purity Germanium detector was used to determine naturally occurring radionuclide...

Pacific herring, Clupea pallasi, were exposed both acutely (96 h) and chronically (9 wk) to the water-soluble fraction (WSF) of North Slope crude oil. Initial mean total PAH concentrations were approximately 10, 40 and 100 μg/L. Biological availability was suggested by a significant induction of hepatic cytochrome P450 content, ethoxyresorufin O-deethylase and glutathione S-transferase activiti...

In this study, we investigated the suppressive effect of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (DL-PCBs) transfer from the feed to the eggs of laying hens by using activated carbon as a feed additive. Four groups of six hens (White Leghorn egg-layers; age, 11weeks) were housed as two control groups and two exp...