Fibroblast cultures derived from human basal cell carcinomas demonstrated an increased capacity to synthesize and secrete collagenase. Although the levels of collagenase were up to 8-fold greater than those of normal control cell lines, this phenotypic trait was not permanent and was expressed only for a few passages following primary explanation. The basal cell carcinoma fibroblast collagenase...

Fibroblast cultures derived from human basal cell carcino mas demonstrated an increased capacity to synthesize and secrete collagenase. Although the levels of collagenase were up to 8-fold greater than those of normal control cell lines, this phenotypic trait was not permanent and was expressed only for a few passages following primary explantation. The basal cell carcinoma fibroblast collagena...

background: glioma is the most common primary brain tumor with poor prognosis. temozolomide (tmz) has been used with irradiation (ir) to treat gliomas. the aim of the present study was to evaluate the cytotoxic and radiosensitizing effect of tmz when combined with high-dose and high-dose rate of gamma irradiation in vitro. methods: two ‘u87mg’ cell lines and skin fibroblast were cultured and as...

Basic fibroblast growth factor (bFGF) and acidic fibroblast growth factor (aFGF) are involved in the induction of embryonic mesoderm, angiogenesis, neuronal differentiation, and proliferation and survival of many cell types. In cardiac myocytes their roles are not well understood. Effects of fibroblast growth factors on reexpression of fetal actin genes have been reported. In freshly isolated a...

introduction cellular processes can be controlled by induction or repression of gene expression by introduction of exogenous genes and rna interference (rnai), respectively. however, the use of recently-developed specific dna-binding transcription factors offer various advantages when compared to the exogenous gene introduction and rnai for up or down regulation of gene expression. sox2 gene en...

Marine Streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. The cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (DMEHE) from marine derived actinomycete Streptomyces sp. VITSJK8 was investigated against mouse embryonic fi...