abstract background: gastric cancer is one of the most common cancers in the world especially in iran. there are many genomic and molecular factors that cause gastric cancer to occur. also, many markers that associate with tumor invasiveness have been known.  e-cadherin is a calcium- mediated cell adhesion molecule. in some studies, abnormal expression of e-cadherin has been seen in gastric car...

Suppression of aberrant DNA methylation is a novel approach to cancer prevention, but, so far, the efficacy of the strategy has not been evaluated in cancers associated with chronic inflammation. Gastric cancers induced by Helicobacter pylori infection are known to involve aberrant DNA methylation and associated with severe chronic inflammation in their early stages. Here, we aimed to clarify w...

BACKGROUND Altered expression of lamins A/C and B1, constituent proteins of the nuclear lamina, may occur during differentiation and has also been reported in primary lung cancer. AIMS To examine the expression of these proteins in gastrointestinal neoplasms. PATIENTS Archival human paraffin wax blocks and frozen tissue from patients undergoing surgical resection or endoscopic biopsy. MET...

The gastric- and intestinal-type properties of 15 human gastric cancers, which were transplanted into nude mice, were studied biochemically and histologically. Enzyme activities were determined in the crude extracts of cancer tissues: pepsinogen isozymes as gastric marker enzymes; and sucrase, aminopeptidase (microsomal), and alkaline phosphatase as intestinal marker enzymes. By hematoxylin and...

BACKGROUND A few studies have indicated inverse relationships between serum ghrelin and gastric and esophageal cancers but those associations have been restricted to specific populations, including smokers and overweight individuals. We examined the association between ghrelin and gastroesophageal cancers and atrophic gastritis in a population-based setting. METHODS In total 220 gastroesophag...

Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth factor receptor family having tyrosine kinase activity. Dimerization of the receptor results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways leading to cell proliferation and tumorigenesis. Amplification or overexpressio...

Gastric cancer is one of the most commonly occurring malignant cancers in the world. Dur‐ ing the second half of the 20th century a drastic rise has been observed in the number of cases and deaths caused by this cancer. Gastric cancer is the second, after pulmonary cancer, cause of death due to malignant cancers in the world. There is a geographic diversification in the occurrence of gastric ca...

cancer and the intestinal type of gastric cancer usually follows stepwise progression with recognizable pre-neoplastic changes (i.e., adenoma and intestinal metaplasia for colorectal and gastric cancers, respectively). Therefore, screening and early diagnosis remain the preferred options to ease the disease burden. Surgical resection is the mainstay treatment for gastrointestinal cancers. Other...

Transforming growth factor-beta 1 (TGF-beta1) inhibits the proliferation of tumors in early stages of cancers, whereas it promotes tumor growth and metastasis in later stages of cancers. To examine the effect of the TGF-beta1 polymorphisms on gastric cancer risk, we studied the association between C-509T and T+29C (Leu10Pro) polymorphisms in TGF-beta1 and gastric cancer risk in 414 cases and 41...