Sepsis is one of the leading causes of death worldwide. While the management of critically ill patients with sepsis is certainly better now compared to 20 years ago, sepsis-associated mortality remains unacceptably high. Annual deaths from sepsis in both children and adults far surpass the number of deaths from acute myocardial infarction (AMI), stroke, or cancer. Given the substantial toll tha...

for GSA Today article 528A: Answering Geosciences Research Questions at a Global Scale via Hybrid Machine-Human Learning Approach: A Case Study of the Link between Climate and Volcanism by Seongjin Park et al.

delta-Aminolevulinic acid (ALA), the universal biosynthetic precursor of tetrapyrrole pigments, is synthesized from glutamate in plants, algae, and many bacteria via a three-step process that begins with activation by ligation of glutamate to tRNA(Glu), followed by reduction to glutamate-1-semialdehyde (GSA) and conversion of GSA to ALA. The GSA aminotransferase step requires no substrate other...

UNLABELLED The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT. METHODS Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study. 99mTc-GSA dynamic SPE...

I examine how firms use alliances to respond to the alliance networks of their rivals, by either allying with their rivals’ partners or by building countervailing alliances. Evidence from the global airline industry (1994–98) suggests that these strategic responses depend on alliance cospecialization. Cospecialized alliances by rivals may involve exclusivity, precluding alliances with the rival...

Despite the fact that it is preventable, dental caries remains a global public health problem—even with fluoride intervention—and it is the most common chronic disease on the planet. Moreover, researchers have already shown for some years that caries is a disease continuum that at the early stages is reversible, yet many Ministries of Health and dental professionals misunderstand this. We belie...

Introduction: Beat-to-beat variation in heart rate shows a complex dynamics, and this complexity is changed during systemic inflammatory response syndrome (e.g. sepsis). It is not known whether or not cardiac pacemaker dynamical rhythm is affected by sepsis. The aim of this study was to investigate heart rate dynamics of isolated heart as well as expression of pacemaker channels (HCN) in a r...

UNLABELLED Small-animal models are crucial to gain insights in the complex recovery mechanisms of liver function during liver regeneration. (99m)Tc-Mebrofenin hepatobiliary scintigraphy (HBS) has been introduced for noninvasive assessment of liver function in the clinical setting as well as in experimental research. However, HBS is restricted to planar modalities in small animals because hepati...

The concept of intelligently controlling the search process of gravitational search algorithm (GSA) is introduced to develop a novel data mining technique. The proposed method is called fuzzy GSA miner (FGSA-miner). At first a fuzzy controller is designed for adaptively controlling the gravitational coefficient and the number of effective objects, as two important parameters which play major ro...

Numerical simulators are widely used to model physical phenomena and global sensitivity analysis (GSA) aims at studying the impact of input uncertainties on simulator output. To perform GSA, statistical tools based inputs/output dependence measures commonly used. We focus here Hilbert–Schmidt independence criterion (HSIC). Sometimes, probability distributions modeling uncertainty inputs may be ...