Gamma-glutamyl transpeptidases (c-GTs) belong to the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the c-glutamyl amide bond of glutathione to give cysteinylglycine. The released c-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). c-GT plays a key role in the gamma-glutamyl cycle by regulating the cellular levels ...

The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were publ...

Gamma-glutamyl transpeptidases (c-GTs) belong to the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the c-glutamyl amide bond of glutathione to give cysteinylglycine. The released c-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). c-GT plays a key role in the gamma-glutamyl cycle by regulating the cellular levels ...

Gamma-glutamyl transpeptidases (c-GTs) belong to the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the c-glutamyl amide bond of glutathione to give cysteinylglycine. The released c-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). c-GT plays a key role in the gamma-glutamyl cycle by regulating the cellular levels ...

Both human herpes viruses and Chlamydia are highly prevalent in the human population and are detected together in different human disorders. Here, we demonstrate that co-infection with human herpes virus 6 (HHV6) interferes with the developmental cycle of C. trachomatis and induces persistence. Induction of chlamydial persistence by HHV6 is independent of productive virus infection, but require...

Objective(s): The current study was conducted to examine the possible protective and retentive effects of one-week intra-peritoneal (IP) administration of selenium nanoparticles (Se-NPs), compared to its bulk counterpart, selenite sodium (Ss), after one complete cycle of spermatogenesis in mature male mice. Materials and Methods: Thirty adult male mice were divided into 3 groups. Control group ...

Experiments were carried out to investigate whether or not the cell cycle dependent cytotoxicity of adriamycin (ADR) was a consequence of variations in cellular glutathione (GSH) levels in different phases of the cell cycle. The GSH content of a range of rodent and human tumor cell lines, grown both in vivo and in vitro, were measured by high performance liquid chromatography. Enrichment of cel...

The most common form of cataract is the “Senile Cataract” occurring in the aged population, which has great socio-medical prevalence for many third world countries, where annually 2-3 million people become blind due to cataract. The cause and phenomenon of cataract development may be same but the changes related with γglutamyl transpeptidase (GTP) activity depends on age and types of cataract. ...

We investigated the effects of different concentrations (0, 1, 2 and 4 mM) of putrescine on chilling injury, fruit quality, ethylene production rate, fatty acid composition and the antioxidant system of cold-stored kiwifruit (Actinidia chinensis Planch. var. chinensis 'Hongyang'). We achieved a significant decrease in ethylene production, maintained fruit quality and alleviated chilling injury ...