Epinephrine increases glycogen synthase (GS) phosphorylation and decreases GS activity but also stimulates glycogen breakdown, and low glycogen content normally activates GS. To test the hypothesis that glycogen content directly regulates GS phosphorylation, glycogen breakdown was stimulated in condition with decreased GS activation. Saline or epinephrine (0.02 mg/100 g rat) was injected subcut...

Figure Legend: Figure 1 Glycogen accumulation–normal accumulation in hepatocytes in a female B6C3F1 mouse from a chronic study. Figure 2 Glycogen accumulation–normal mobilization of glycogen from centrilobular area in a male B6C3F1 mouse from a subchronic study. Figure 3 Glycogen accumulation–glycogen in all hepatocytes in a male B6C3F1 mouse from a subchronic study. Figure 4 Glycogen depletion...

hydroxyproline level when the alkaline phosphatase level is of the order found in this patient. Further evidence of normal bone metabolism was obtained from the normal hydroxyproline excretion. There was no laboratory evidence to suggest hyperparathyroidism. The normal galatose-l-phosphate uridyl transferase level ruled out galactosaemia. Though a diagnosis of glycogen storage disease was consi...

The effects of minimal increments in plasma insulin concentrations on hepatic glucose production and glucose uptake, skeletal muscle net glycogen synthesis and glycogenolysis, glycogen synthase and phosphorylase activity, glucose-6-phosphate and uridinediphosphoglucose (UDPG) concentrations were examined in 24-h and in 6-h fasted conscious rats. Insulin was infused for 120 min at rates of 1.5, ...

background: the present work was planned to evaluate the antihyperglycemic, lipid‑lowering, and antioxidant effect of lactobacillus casei and bifidobacterium bifidum in streptozotocin (stz)‑induced diabetic rats. methods: single daily dose of 1 × 107 cfu/ml of l. casei and b. bifidum alone and in combination of both was given to wistar rats orally by gavaging for 28 days. glucose tolerance test...

1. Minced muscle and liver of normal rats produce glycogen from glucose-l-phosphate in vitro. 2. If, after a starvation period, the glycogen content falls below 200 mg./100 g., minced liver and muscle do not produce glycogen from glucose-lphosphate. However, if glycogen is added as well, additional glycogen is produced, just as with pure enzyme solutions. 3. In adrenalectomized, adynamic rats t...

to serve as a reference point for this study. All tissue samples were weighed and sub-sampled for glycogen analysis. Liver glycogen (3.1 mg/g liver or 2.8 mg total) and breast glycogen (2.3 mg/g, 3.7 mg total) were 2 and 1.2 times higher, respectively, in the winter than in the summer (P<0.0001). Only during the winter did hatch time affect glycogen status. Total glycogen levels in liver and br...

Glycogen plays a major role in supporting the energy demands of skeletal muscles during high intensity exercise. Despite its importance, the amount of glycogen stored in skeletal muscles is so small that a large fraction of it can be depleted in response to a single bout of high intensity exercise. For this reason, it is generally recommended to ingest food after exercise to replenish rapidly m...

The PHO85 gene of Saccharomyces cerevisiae encodes a cyclin-dependent protein kinase that can interact with 10 different cyclins (Pcls). In conjunction with Pcl8p and Pcl10p, Pho85p phosphorylates and regulates glycogen synthase. Respiratory-deficient strains, such as coq3 mutants, have reduced glycogen stores and contain hyperphosphorylated and inactive glycogen synthase. We show here that pho...