Advances in our understanding of the biology of paediatric central nervous system (CNS) tumours have encouraged pathologists to use molecular markers alongside histopathological analysis for disease classification or prognostication and treatment stratification. In this article, we review molecular genetic alterations in paediatric CNS tumours, including those in low-grade and high-grade glioma...

INTRODUCTION Recent advances in molecular diagnostics allow diffuse gliomas to be classified based on their genetic changes into distinct prognostic subtypes. However, a systematic analysis of all molecular markers has thus far not been performed; most classification schemes use a predefined and select set of genes/molecular markers. Here, we have analysed the TCGA dataset (combined glioblastom...

Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights in...

BACKGROUND In the 2016 update of the World Health Organization Classification of Tumors of the central nervous system, phenotypic and genotypic parameters are integrated in diffuse low-grade glioma (LGG) tumor classification. Implementation of this combined phenotypic-genotypic characterization identifies prognostic relevant subgroups. CASE DESCRIPTION We report a case of a 67-year-old patien...

This paper considers the automatic design of fuzzy rule-basedclassification systems based on labeled data. The classification performance andinterpretability are of major importance in these systems. In this paper, weutilize the distribution of training patterns in decision subspace of each fuzzyrule to improve its initially assigned certainty grade (i.e. rule weight). Ourapproach uses a punish...

-Data Mining is a powerful tool for academic intervention. Mining in education environment is called Educational Data Mining. Educational Data Mining is concerned with developing new methods to discover knowledge from educational database and can used for decision making in educational system. In our work, we collected the student’s data from engineering institute that have different informatio...

The current World Health Organization classification of CNS tumors has made a tremendous leap from past editions by incorporating molecular criteria in addition to the pre-existing histological parameters. The revised version has had a particular impact on the classification of diffuse low-grade gliomas and their high-grade variants. The ATRX status is one of the critical markers that define th...

The aim of this study was to determine the relationship between volar plate removal and the Soong classification following fixation for fractured distal radius. In this retrospective cohort study, all consecutive patients who had volar plate fixation for a distal radius fracture in 2011-2015 were reviewed. Differences in Soong classification between patients who had plate removal and those who ...

One important quality measure of a scientific journal is its scope, not just the scientific coverage, but also the geographical impact. In fact, the primary classification system, used to evaluate and grade scientific journals' quality in Brazil, known as Qualis CAPES, when classifying a journal attributes a quality grade A, B or C, and also adds an indication of the journal ́s geographical impa...

Objective HER-2/neu gene is overexpressed in diverse human cancers and studies suggest a role of its product – p185 protein – in tumor progression by specifically promoting the invasive capacity of tumor cells. Our aim was to evaluate HER-2/neu content in resectable gastric cancer in this geographical region and assess the relationship between p185 expression and clinicopathologic tumor paramet...