The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly. Intriguingly however, depletion of Aly only leads to a modest reduction in cellular mRNA nuclear export, suggesting the existence of additional mRNA nuclear export adaptor proteins. In order to efficiently export Kaposi's sarcoma-assoc...

The production of ribosomes constitutes a major biosynthetic task for cells. Eukaryotic small and large ribosomal subunits are assembled in the nucleolus and independently exported to the cytoplasm. Most nuclear export pathways require RanGTP-binding export receptors. We analyzed the role of CRM1, the export receptor for leucine-rich nuclear export signals (NES), in the biogenesis of ribosomal ...

Protons are utilized for various biological activities such as energy transduction and cell signaling. For construction of the bacterial flagellum, a type III export apparatus utilizes ATP and proton motive force to drive flagellar protein export, but the energy transduction mechanism remains unclear. Here, we have developed a high-resolution pH imaging system to measure local pH differences wi...

Policies are used to control the behavior of large-scale systems. After policies are designed and before policies are implemented, it should be possible to analyze the policies and verify that they behave as expected. Graph transformations provide a good method to carry out the analysis and verification because of the intuitive representation of policies and the mature theory. Here, we show how...

A phase-field approach for quantitative simulations of grain growth in anisotropic systems is introduced, together with a new methodology to derive appropriate model parameters that reproduce given misorientation and inclination dependent grain boundary energy and mobility in the simulations. The proposed model formulation and parameter choice guarantee a constant diffuse interface width and co...

Note that if ∑ agg ∈ I, then ∑ ag = 0 so that ∑ agg = ∑ agg− ∑ ag1 = ∑ ag(g−1), so that every element in I is a Z-linear combination of the elements g− 1 (g ∈ G, g 6= 1). Also, if ∑ ag(g− 1) = 0, it follows that ag = 0 for all g so that the elements g − 1 (g ∈ G, g 6= 1) are linearly independent. (b) Notice that the ideal generated by the elements s− 1 (s ∈ S) is the same as the ideal generated...

This paper tries to define the concept of Export Finance and establish if the Export Financing is cost-effective way to raise capital and how is it organized in the Russian Federation. In order to do so, several methods have been used: the related literature has been studied, numerical analysis of economic-efficience of export financing has been prepared based on the real example and three inte...