OBJECTIVE We present the case of a 14-year-old Factor VIII-deficient patient with no history of trauma, who developed acute spontaneous compartment syndrome of the volar forearm. We also suggest a treatment strategy. METHODS Fasciotomy with hematoma evacuation and ipsilateral carpal tunnel release was performed, and the wound was closed with vascular loops in "Jacob's ladder" fashion. Factor ...

Aim: The aim of the study was to investigate whether multimorbidities, comorbidities, and therefore polypharmacy increase with age in hemophilia A B patients followed Ege University Adult Hemophilia Thrombosis Center. Materials Methods: were retrospectively evaluated. Patients'demographic data, medical information about hemophilic arthropathy, viral infections hepatitis C virus (HCV), body mass...

To evaluate the safety and efficacy of didanosine (ddl) monotherapy and three different combinations of zidovudine (ZDV) and ddl in asymptomatic human immunodeficiency virus-l (HIV-1) infection, we conducted an open-label, phase 1/11 study in 126 asymptomatic HIV-l-infected hemophilic and nonhemophilic subjects with a CD4 count of 200 to 500/mm3 stratified for prior zidovudine treatment and bas...

Joint bleeding is a common occurrence for people with hemophilia and, if untreated, can result in hemophilic arthropathy. Ultrasound imaging has recently emerged as an effective tool to diagnose the distension of joint recess caused by bleeding. However, no computer-aided diagnosis exists support practitioner process. This paper addresses problem automatically detecting subquadricipital knee an...

A 29-year-old male patient presented with progressive deformity of his left elbow since childhood. He was constantly treated with factor VIII for severe hemophilia A. He stated that he had no other diseases and had been submitted to any surgeries. At physical examination, he presented with restricted elbow extension (Figure 1A) and had a similar deformity of the right elbow. The patient is nega...

Approximately 25% of hemophilia A patients infused with factor VIII (fVIII) mount an immune response, which leads to its inactivation. Anti-fVIII autoantibodies are also seen rarely in individuals with normal fVIII. We have previously demonstrated that some anti-A2 and anti-C2 domain antibodies are fVIII inhibitors and that many patients have additional inhibitors with a fVIII light chain (LCh)...

Approximately 25% of hemophilia A patients infused with hemophilic plasmas, but only 33% (7 of 21) of autoantibody factor VIII (fVIII) mount an immune response, which leads plasmas. These results demonstrated that the inhibitor reto its inactivation. Anti-fVIII autoantibodies are also seen sponse in hemophiliacs was more complex and the epitope rarely in individuals with normal fVIII. We have p...

The seventh edition of the haemophilia B database lists in easily accessible form all known factor IX mutations due to small changes (base substitutions and short additions and/or deletions of <30 bp) identified in haemophilia B patients. The 1535 patient entries are ordered by the nucleotide number of their mutation. Where known, details are given on: factor IX activity, factor IX antigen in c...