In the last half of the 20th century, use of the liver biopsy has grown to serve multiple purposes: (1) confirmation of clinical diagnosis, (2) assessment of severity of necroinflammation and fibrosis, (3) evaluation of possible concomitant disease processes, and (4) assessment of therapeutic intervention. The current practice for reporting histopathological evaluation of chronic hepatitis invo...

OBJECTIVE To determine the correlation between degree of histological liver damage and serum HCV RNA level in patients of chronic hepatitis C, in order to evaluate the usefulness of HCV RNA estimation as an alternate to liver biopsy. METHODS This non-interventional descriptive study, was carried out at the department of Pathology, Army Medical College, Rawalpindi, Pakistan between April and S...

BACKGROUND Type I interferons have pleiotropic effects on host cells, including inhibiting telomerase in lymphocytes and antiviral activity. We tested the hypothesis that long-term interferon treatment would result in significant reduction in average telomere length in peripheral blood T lymphocytes. METHODS/PRINCIPAL FINDINGS Using a flow cytometry-based telomere length assay on peripheral b...

Interferon (IFN) provides effective treatment in some patients with chronic hepatitis. The clarification of factors predictive of therapy response would be helpful in identifying patients who would benefit from treatment. In this study, we evaluated the potential utility of Tc-99m sulfur colloid liver/spleen and Tc-99m-disofenin hepatobiliary scintigraphy to predict therapy response to IFN in p...

BACKGROUND The mechanisms leading to hepatic injury in chronic hepatitis C virus (HCV) infection are only incompletely understood. Recent data propose a correlation of the intrahepatic expression of the CC chemokine RANTES and the degree of periportal and portal inflammatory liver damage. AIM Here, we have studied the intrahepatic mRNA levels of CC chemokines RANTES together with that of othe...

PURPOSE To evaluate the effect of hepatitis activity on liver stiffness measurements and the role of serum alanine aminotransferase (ALT) in liver fibrosis staging by MR elastography (MRE). MATERIALS AND METHODS We measured liver stiffness (kPa) in 135 patients by MRE and histologically assessed fibrosis and hepatitis activity within 2 months. Stepwise multiple linear regression was performed...

Antimicrobial peptides are host defense peptides being viewed as replacement to broad-spectrum antibiotics due to varied advantages. Hepatitis is the commonest infectious disease of liver, affecting 500 million globally with reported adverse side effects in treatment therapy. Antimicrobial peptides active against hepatitis are called as anti-hepatitis peptides (AHP). In current work, we present...

Hepatocyte expression of pre-S1 and pre-S2 in relation to hepatitis B virus replication (hepatitis B virus-DNA in serum and HBcAg in the liver), histological activity and hepatitis delta virus superinfection was studied by indirect immunofluorescence on frozen sections of liver specimens from 68 patients with chronic hepatitis B virus infection. All 44 patients with chronic type B hepatitis had...

Hyperglycemia and insulin resistance are associated with morbidity mortality in critically ill patients, patients diabetes mellitus, alcoholic hepatitis, postoperative patients. Low GI (glycemic index) foods help control blood sugar resistance. Therefore, the goal of study was to determine glycemic index 4 kinds milk for subjects whose hyperglycemia affected treatment outcomes, namely, (proanec...

In infections with the hepatitis C virus (HCV), there is a wide spectrum of histological alterations that can affect the liver, from acute hepatitis to mild reactive phenomena to more severe forms, including chronic hepatitis with varying degrees of inflammation/fibrosis, cirrhosis, and hepatocellular carcinoma. In cases of acute hepatitis C, biopsies are rare, pathologists focusing their atten...