OBJECTIVE This study aims to investigate the characters of pregnant women and neonates with listeria monocytogenes infections (L. monocytogenes) in Shandong of China. METHOD Pregnant women with premature delivery or prenatal fever were recruited in 2013. Bacterial culture was performed for the umbilical cord blood and placental swab after delivery. The strains isolated were then analyzed for ...

The biochemical and serological characteristics, virulence properties, and genetic relatedness of Shiga toxin-producing Escherichia coli (STEC) strains isolated in S o Paulo, from April 1989 through March 1990, were determined. This is also the first report on clinic findings of human STEC infections in Brazil. The only three STEC strains identified in that period were lysine decarboxylase nega...

Pathogens have developed intricate strategies to overcome the host’s innate immune responses. In this paper we use live-cell microscopy with a single bacterium resolution follow in real time interactions between food-borne pathogen L. monocytogenes and host macrophages, key event controlling infection vivo . We demonstrate that results heterogeneous outcomes, only subset of bacteria able establ...

Listeria monocytogenes is a significant food-borne pathogen and the causative agent of listeriosis, a disease which manifests as meningitis in immunocompromised adults or infection of the fetus and miscarriage in pregnant women. We have previously used Lactococcus lactis, a GRAS (Generally Regarded As Safe) organism, as a vaccine vector against listeriosis by engineering plasmid-mediated expres...

BACKGROUND: Escherichia coli (E.coli) is one of the most common and important causative bacterium of urinary tract infections (UTIs) in both dogs and humans. OBJECTIVES: This study aimed to identify virulence genes and a phylogenetic group of E. coli isolated from the urine of dogs suffering from UTIs. METHODS: <em...

Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited knowledge their ligand regulation or structure is available1–3. Here we report that glucocorticoid stress hormones activate adhesion receptor G3 (ADGRG3; also known as GPR97)4–6, prototypical GPCR. The cryo-electron microscopy structures GPR97–Go complexes bound to the anti-inflammatory drug beclomethasone ste...