The complex interplay between the response regulator ComA, the anti-activator RapF, and the signaling peptide PhrF controls competence development in Bacillus subtilis. More specifically, ComA drives the expression of genetic competence genes, while RapF inhibits the interaction of ComA with its target promoters. The signaling peptide PhrF accumulates at high cell density and upregulates geneti...

Coma blisters are lesions that occur in the setting of a variety of neurological diseases. Although most commonly associated with barbiturate overdose, they can be seen in the setting of coma due to other etiologies. Blisters develop 48-72 h after the onset of unconsciousness. We report the case of a 29-year-old man who presented to the emergency department with confusion and progressive loss o...

I find that when I eat lunch I can feel myself instantly get tired as if a wave passes through me. My face gets a feeling of being sweaty and flushed. Coffee and copious amounts of water help counteract this. Also, it doesn't happen every day with every meal. Very small amounts of food don't cause this. It's as if I eat above a small threshold, then it happens. It makes it hard to work. A short...

Coma stimulation is a treatment in which a health care professional or a patient's family member systematically applies stimulation to one or more of the patient's five senses, for the purpose of increasing patient responsiveness. The rationale is that exposure to frequent and various sensory stimulation will facilitate both dendritic growth and improve synaptic connectivity in those with damag...

Since the Glasgow Coma Scale was introduced in 1974,(1) it has become the most common method of describing a patient's level of consciousness. However, despite its almost universal use, there remain a number of misunderstandings, particularly regarding the appropriate situations in which to use the Glasgow Coma Score rather than the Scale, and also in the correct way to elicit and record the mo...